952494-05-2

Basic information

• Product Name: 2-{5-[2-(tert-butyldimethylsilanyloxy)-ethyl]-imidazol-1-ylmethyl}-benzonitrile
• Synonyms: 2-{5-[2-(tert-butyldimethylsilanyloxy)-ethyl]-imidazol-1-ylmethyl}-benzonitrile
• CAS NO: 952494-05-2
• Molecular Weight: 341.528
• Mol File: 952494-05-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{5-[2-(tert-butyldimethylsilanyloxy)-ethyl]-imidazol-1-ylmethyl}-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{5-[2-(tert-butyldimethylsilanyloxy)-ethyl]-imidazol-1-ylmethyl}-benzonitrile(952494-05-2)
• EPA Substance Registry System: 2-{5-[2-(tert-butyldimethylsilanyloxy)-ethyl]-imidazol-1-ylmethyl}-benzonitrile(952494-05-2)

Safety Data

• Hazardous Substances Data: 952494-05-2(Hazardous Substances Data)

Upstream product

• 168632-03-9 1-triphenylmethyl-4-imidazolyl-acetic acid 
• 127607-62-9 1-triphenylmethyl-4-(2-hydroxyethyl)-1H-imidazole 
• 3251-69-2 imidazole-4-acetic acid hydrochloride 
• 928136-82-7 4-[2-[(tert-butyldimethylsilyl)oxy]ethyl]-1-(triphenylmethyl)-1H-imidazole 
• 22115-41-9 2-(bromomethyl)benzonitrile 

Relevant articles and documents

ORGANIC COMPOUNDS

The present invention provides a compound of formula (I):said compound is inhibitor of aldosterone synthase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, increased formation of collagen, cardiac fibrosis and remodeling following hypertension and endothelial dysfunction. Finally, the present invention also provides a pharmaceutical composition.