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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Benzenepropanoic acid, α,β,4-tribromo, ethyl ester is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows it to be a valuable building block for the development of new drugs and pesticides.
Used in Medicinal Chemistry and Drug Development:
Due to its distinctive chemical properties, Benzenepropanoic acid, α,β,4-tribromo, ethyl ester is employed as a component in medicinal chemistry research and drug development. It can be used to create new compounds with potential therapeutic effects.
Used as a Reagent in Organic Synthesis:
Benzenepropanoic acid, α,β,4-tribromo, ethyl ester can also be utilized as a reagent in organic synthesis and other chemical reactions, contributing to the formation of complex organic molecules.
Safety Precautions:
It is crucial to handle Benzenepropanoic acid, α,β,4-tribromo, ethyl ester with care due to its hazardous nature and potential health risks. Proper safety measures should be taken to minimize exposure and ensure the well-being of those working with Benzenepropanoic acid, .alpha.,.beta.,4-tribroMo-, ethyl ester.

Upstream product

• 24393-53-1 ethyl (E)-3-(4-bromophenyl)-2-propenoate 
• 24393-53-1 ethyl 4-bromocinnamate 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 25294-65-9 3-(4-bromophenyl)-2-propynoic acid 
• 1088410-99-4 3-(4-bromophenyl)-1-methylpyrrolidine 

Relevant academic research and scientific papers

Practical asymmetric hydrogenation-based synthesis of a class-selective histone deacetylase inhibitor

Two syntheses of the class-selective histone deacetylase inhibitor 1 are reported. In the first, eight-step entailing synthesis, the key transformations were a highly efficient [3 + 2] dipolar cycloaddition affording trans-rac-5 and its resolution. In the

Organocatalysis as a safe practical method for the stereospecific dibromination of unsaturated compounds

Organocatalytic stereospecific dibromination of a wide variety of functionalized alkenes was achieved using a stable, inexpensive halogen source, 1,3-dibromo 5,5-dimethylhydantoin, and a simple thiourea catalyst at room temperature. The presence of a tertiary amine enhanced the rate of the dibromination reaction, and yields were good in various solvents, including aqueous solvents. The procedure was extended to alkynes and aromatic rings and to dichlorination reactions by using the 1,3-dichloro hydantoin derivative.

Transmission of substituent effects through extended systems-III. p-Substituted ethyl trans cinnamates and phenylpropiolates

Infrared data and 13C chemical shifts are reported for a series of ethyl p-substituted trans-cinnamates and ethyl phenylpropiolates.The i.r. values include intensities for the benzene, ethylene and carbonyl vibrations which allow an estimation of resonance effects.The relative importance of the various mechanisms of transmission of substituent effects are discussed and compared to those previously reported for p-substituted trans cinnamonitriles.It is shown that the carbon-carbon triple bond is less efficient in transmitting substituent effects than carbon-carbon double bonds.