952648-77-0 Usage
Type of compound
Semi-synthetic analog of the anthracycline compound epirubicin and a derivative of doxorubicin.
Classification
Cytotoxic anthracycline antibiotic.
Mechanism of action
Intercalates DNA and inhibits topoisomerase II, leading to the inhibition of DNA and RNA synthesis.
Medical use
Chemotherapeutic agent for the treatment of various cancers.
Cancer types treated
Breast, lung, and ovarian cancers.
Efficacy
Demonstrated comparable efficacy to epirubicin.
Cardiotoxicity
Displays a lower incidence of cardiotoxicity compared to epirubicin.
Potential alternative
Suitable for patients with preexisting cardiac conditions or at risk of cardiotoxicity from anthracycline therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 952648-77-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,2,6,4 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 952648-77:
(8*9)+(7*5)+(6*2)+(5*6)+(4*4)+(3*8)+(2*7)+(1*7)=210
210 % 10 = 0
So 952648-77-0 is a valid CAS Registry Number.
InChI:InChI=1/C27H31NO10/c1-11-22(30)14(28)8-17(37-11)38-16-10-27(35,6-7-29)9-13-19(16)26(34)21-20(24(13)32)23(31)12-4-3-5-15(36-2)18(12)25(21)33/h3-5,11,14,16-17,22,29-30,32,34-35H,6-10,28H2,1-2H3
