Cas 952650-10-1,7-bromo-1-(4-trifluoromethylphenylamino)-5-cyclopropyl-8-[3-(4-morpholinyl)propoxy]-5H-pyridazino[4,5-b]indole

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Check Digit Verification of cas no

The CAS Registry Mumber 952650-10-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,2,6,5 and 0 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 952650-10:
(8*9)+(7*5)+(6*2)+(5*6)+(4*5)+(3*0)+(2*1)+(1*0)=171
171 % 10 = 1
So 952650-10-1 is a valid CAS Registry Number.

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952650-10-1Relevant academic research and scientific papers

Synthesis and anti-tumor activities of a novel series of tricyclic 1-anilino-5H-pyridazino[4,5-b]indoles

Rong, Dong Li,Zhai, Xin,Yan, Fang Zhao,Yu, Shuang,Gong, Ping

, p. 424 - 428 (2008/12/21)

A novel series of 1-anilino-5H-pyridazino[4,5-b]indoles was designed and synthesized in order to find novel potent anti-tumor compounds. Their structures were confirmed by MS, 1H-NMR, and elemental analysis. All compounds were screened for their cytotoxic activity against two human cancer cell lines (Bel-7420, HT-1080). The compounds 8, 9, and 17 showed 50% growth inhibitory activity in low micromolar concentration (IC50 = 7.7～12.8 μM). Among them, compound 17 displayed the most potent anti-tumor activity with IC50 values of 8.2 μM and 7.9 μM against Bel-7402 and HT-1080, respectively.

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