952685-46-0

Upstream product

• 118388-73-1 (S)-2-tert-butyl 1-cyclohexyl-4-diazo-3-oxobutan-2-ylcarbamate 
• 37736-82-6 (S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid 
• 150831-65-5 (S)-tert-butyl 4-chloro-1-cyclohexyl-3-oxobutan-2-ylcarbamate 

Downstream Products

• 952685-52-8 (2R,3S)-3-(tert-butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H)-fluoren-9-yl)methoxycarbonylamino)butan-2-ol 
• 952685-79-9 3-((2S,3R)-4-(N-(4-cyanobenzyl)-N-(2-trimethylsilylethoxycarbonyl)amino)-1-cyclohexyl-3-hydroxybutan-2-ylamino)-4-methoxycyclobut-3-ene-1,2-dione 
• 952685-81-3 3-((2S,3R)-4-azido-1-cyclohexyl-3-hydroxybutan-2-ylamino)-4-(3-((3-methoxypropoxy)(phenyl)methyl)piperidin-1-yl)cyclobut-3-ene-1,2-dione 
• 952685-54-0 tert-butyl (2S,3R)-4-(N-(4-cyanobenzylamino)-N-(2-trimethylsilylethoxycarbonyl)amino)-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate 
• 952685-55-1 (2S,3R)-3-amino-1-(N-(4-cyanobenzyl)-N-(2-trimethylsilylethoxycarbonyl)amino)-4-cyclohexylbutan-2-ol 
• 952685-51-7 tert-butyl (2S,3R)-1-cyclohexyl-4-(3,5-dimethoxybenzylamino)-3-hydroxybutan-2-ylcarbamate 
• 952685-53-9 tert-butyl (2S,3R)-4-(4-cyanobenzylamino)-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate 
• 952685-58-4 (2R,3S)-3-amino-1-azido-4-cyclohexylbutan-2-ol hydrochloride 
• 952685-80-2 3-((2S,3R)-4-azido-1-cyclohexyl-3-hydroxybutan-2-ylamino)-4-methoxycyclobut-3-ene-1,2-dione 
• 107202-62-0 tert-butyl (S)-2-cyclohexyl-1-((S)-oxiran-2-yl)ethylcarbamate 

Relevant academic research and scientific papers

DIAMINOPROPANOL RENIN INHIBITORS

Described are diaminopropanols of which are orally active and bind to renin to inhibit its activity. They are useful in the treatment or amelioration of diseases associated with elevated levels of renin activity or in the treatment of aspartic protease me

Aminodiol HIV Protease Inhibitors. 1. Design, Synthesis, and Preliminary SAR

A series of HIV protease inhibitors containing a novel C2 symmetrical "aminodiol" core structure were prepared from amino acid starting materials.The ability of the aminodiols to inhibit HIV replication in cell culture is comparable to their ability to inhibit the isolated enzyme, a result compatible with good cell membrane penetration by this class of compounds.Optimization of the structure-activity in this series led to aminodiol 9a (Ki = 100 nM; ED50(HIV-1) = 80 nM) containing P1/P1' benzyl and P2/P2' Boc substituents.Compound 9a is a selective inhibito r of HIV protease versus other aspartyl proteases such as human renin, human cathepsin D, and porcine pepsin.In addition, 9a is equipotent against HIV-1 and HIV-2 in cell culture and demonstrates similar activity in infected T-lymphocytes and PBMCs.After iv and oral administration in rats, 9a displayed significant oral bioavailability (ca. 40percent) and a promising plasma elimination half-life (4 h).