952708-30-4

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 201601-50-5 (3S,4S)-1-benzyl-3-(tert-butyldimethylsilyl)oxy-4-hydroxypyrrolidine 
• 90365-74-5 (3S,4S)-(+)-1-benzyl-3,4-pyrrolidinediol 
• 267234-14-0 (3R,4S)-3-azido-1-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine 

Downstream Products

• 952709-09-0 tert-butyl (3R,4S)-4-(tert-butyldimethylsilyloxy)-1-((2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine-4-carbonyl)pyrrolidin-3-ylcarbamate 

Relevant academic research and scientific papers

RENIN INHIBITORS

Disclosed are compounds according to Formula (I): wherein the variables are defined herein. Such compounds are can bind aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic pro

Synthesis of enantiopure protected 3-hydroxy-4-amino pyrroline N-oxides

The synthesis of new five-membered enantiopure cyclic nitrones bearing protected cis vicinal amino and hydroxy functionalities is reported. The key step was a Mitsunobu reaction, which allowed placement of an azido group, with inversion of configuration, at the reacting centre. Cycloaddition of the novel nitrones to but-3-en-1-ol followed by simple elaboration of the adducts readily afforded protected amino dihydroxy indolizidines. (C) 2000 Elsevier Science Ltd.