952739-80-9Relevant academic research and scientific papers
An expedient, scalable synthesis of the natural product L-anserine
Wiles, Charlotte,Watts, Paul
, p. 2608 - 2610 (2008/02/13)
To date, the synthesis of L-anserine has relied on the use of naturally occurring 1-methyl-L-histidine as a precursor, however its high cost prevents its use in the large-scale synthesis of L-anserine. With this in mind, we report herein a concise and efficient synthetic strategy, employing the 160-fold less expensive, L-histidine methyl ester dihydrochloride as a starting material, to afford the title compound in an overall yield of 88%, over four reaction steps. Georg Thieme Verlag Stuttgart.
