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Usage

Uses

Used in Pharmaceutical Industry:
10-Acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide is used as a key intermediate in the synthesis of Oxacarbazepine, a medication used for the treatment of epilepsy. It plays a crucial role in the production of this anticonvulsant drug, which helps control seizures and manage epilepsy symptoms.
In the synthesis process, 10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide is transformed into Oxacarbazepine through a series of chemical reactions. This intermediate compound is essential for the development of new Oxacarbazepine-related compounds, potentially leading to the discovery of more effective treatments for epilepsy and other neurological disorders.
Overall, 10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide is a vital component in the pharmaceutical industry, contributing to the production of life-saving medications and the advancement of research in the field of epilepsy treatment.

Upstream product

• 28721-07-5 oxcarbazepine 
• 108-24-7 acetic anhydride 
• 4698-11-7 10-methoxy-5H-dibenzo[b,f]azepine 

Downstream Products

• 186694-45-1 eslicarbazepine acetate 
• 186694-45-1 (+)-Licarbazepine acetate 

Relevant academic research and scientific papers

Synthesis and characterization of potential impurities of Oxcarbazepine drug substance: An antiepileptic agent

Oxcarbazepine is a drug substance used to treat epilepsy. During its bulk synthesis of various impurities formation will be observed. Herein we describe the formation, synthesis and characterization of four potential impurities, namely, N-acetyl Oxcarbazepine, N-formyl Oxcarbazepine, N-carbamoyl Oxcarbazepine, and Oxcarbazepine dimer. These impurities are listed in several Pharmacopoeias and the control of these impurities below the threshold level is essential. Our study will be a guide for making these reference standards.

PREPARATION OF ESLICARBAZEPINE AND RELATED COMPOUNDS BY ASYMMETRIC HYDROGENATION

A process for preparing a compound of the formula IA or IB, wherein R is a!kyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalkyl represents a saturated alicyclic gτoup with 3 to 6 carbon atoms; the term aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II, wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.