952747-27-2

Usage

Uses

Used in Organic Synthesis:
(S)-3-(aminooxy)pyrrolidin-1-carboxylic acid tert-butyl ester is used as a protecting group for proline in peptide synthesis. The tert-butyl ester group provides stability and protection for the carboxylic acid functionality, which is crucial for the successful synthesis of peptides without unwanted side reactions.
Used in Drug Development:
In the pharmaceutical industry, (S)-3-(aminooxy)pyrrolidin-1-carboxylic acid tert-butyl ester is used as a chiral building block for the preparation of various pharmaceuticals and agrochemicals. Its unique structure allows for the creation of biologically active compounds with potential therapeutic applications.
Used in Research and Development of Biologically Active Compounds:
(S)-3-(aminooxy)pyrrolidin-1-carboxylic acid tert-butyl ester is an important chemical building block in the research and development of biologically active compounds. Its versatility and the protective nature of the tert-butyl ester group make it a valuable precursor in various synthetic reactions, contributing to the discovery and development of new drugs and other bioactive molecules.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 
• 952747-25-0 (S)-3-[(1,3-dihydro-1,3-dioxo-isoindol-2-yl)oxy]pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1452465-83-6 (3S)-3-[({[(2S,5R)-6-benzyloxy-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]pyrrolidin-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

A PROCESS FOR PREPARATION OF (2S, 5R)-7-OXO-N-[(3S)-PYRROLIDIN-3-YLOXY]-6-(SULFOOXY)-1,6-DIAZABICYCLO [3.2.1]OCTANE-2-CARBOXAMIDE

A process for preparation of a compound of Formula (I) is disclosed.

NOVEL -LACTAMASE INHIBITOR AND METHOD FOR PRODUCING SAME

The currently available β-lactamase inhibitors are insufficient to inhibit the incessantly increasing β-lactamase, and novel β-lactamase inhibitors has been required today for the difficult treatment for bacterial infectious diseases caused by resistant bacteria which produce class C β-lactamase, extended-spectrum β-lactamase (ESBL) belonging to class A and D, or class A KPC-2 decomposing even carbapenem as a last resort for β-lactam antibiotic. A compound represented by the the formula (I), preparation process of the same, β-lactamase inhibitors and method for treating bacterial infectious diseases are provided.

AMINOOXIME DERIVATIVES OF 2- AND/OR 4-SUBSTITUTED ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS

New aminooxime derivatives at position 3 of 2-and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described,where the radicals have the meanings described in detail in the application.

AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE

The invention relates to azabenzofuranyl compounds of Formula (I) with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

AZAHETEROCYCLYL DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS

Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+,K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.