95276-09-8Relevant academic research and scientific papers
Pd-Catalyzed Approach for Assembling 9-Arylacridines via a Cascade Tandem Reaction of 2-(Arylamino)benzonitrile with Arylboronic Acids in Water
Ye, Xuanzeng,Xu, Beihang,Sun, Jiani,Dai, Ling,Shao, Yinlin,Zhang, Yetong,Chen, Jiuxi
, p. 13004 - 13014 (2020/11/23)
A novel palladium-catalyzed protocol for the synthesis of 9-arylacridines via tandem reaction of 2-(arylamino)benzonitrile with arylboronic acids in water has been developed with good functional group tolerance. The present synthetic route could be readily scaled up to gram quantity without difficulty. This methodology was further extended to the synthesis of a 4′-OH derivative, which showed estrogenic biological activity. Preliminary mechanistic experiments showed that this transformation involves a nucleophilic addition of aryl palladium species to the nitrile to generate an aryl ketone intermediate followed by an intramolecular Friedel-Crafts acylation and dehydration to acridines.
Aryl acridine derivative synthesized by palladium catalysis and preparation method thereof (by machine translation)
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Paragraph 0036-0043, (2020/02/14)
When the reaction is carried out, the reaction temperature of the catalyst is very moderate, the reaction 2 - (temperature) of the catalyst is very moderate, the reaction; time of the, catalyst is, very moderate, and the reaction, is carried out at a reaction . temperature ranging from the reaction, time of the; reaction to the, solvent, 90 - 110 °C, 20 - 25, 94%. (by machine translation)
Synthesis of Substituted Acridines through a Palladium-Catalyzed Condensation/Cyclization/Tautomerization Sequence
Chen, Xiangui,Xie, Yanjun,Li, Cheng,Xiao, Fuhong,Deng, Guo-Jun
supporting information, p. 577 - 581 (2017/02/05)
Herein, we report an efficient strategy for the synthesis of 9-aryl-substituted acridines from cyclohexanones and 2-aminobenzophenones in the presence of a palladium catalyst. Molecular oxygen is applied as a green oxidant. Various cyclohexanones acted as the aryl source to construct the nitrogen-containing heterocycles through a condensation/cyclization/tautomerization sequence.
