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Usage

Uses

Used in Agriculture:
Buprofezin [iso] is used as an insecticide for controlling a broad spectrum of pests in various crops. It is applied to protect plants such as cotton, pome fruits, vegetables, and ornamentals from damage caused by insects.
The application reason for using Buprofezin [iso] in agriculture is its effectiveness against pests like whiteflies, scale insects, and leafhoppers, while exhibiting low toxicity towards non-target organisms and the environment. This selective action makes it a preferred choice for integrated pest management strategies.
Formulations and Application Methods:
Buprofezin [iso] is available in different formulations, including emulsifiable concentrates, wettable powders, and soluble concentrates, to suit various application needs. It is typically applied as a foliar spray to ensure even distribution and effective pest control.
Regulation and Resistance Management:
To minimize the risk of resistance development and reduce environmental impact, the use of Buprofezin [iso] is regulated. This includes following recommended application rates and intervals, as well as adopting other pest management practices to preserve the effectiveness of this insecticide and reduce the likelihood of pests developing resistance to its action.

Upstream product

• 52599-24-3 N-tert-butyl-N'-isopropylthiourea 
• 52123-54-3 N-Chloromethyl-N-phenylcarbamoyl chloride 
• 100-61-8 N-methylaniline 
• 590-42-1 tert-butyl isothiocyanate 

Relevant academic research and scientific papers

Method for continuously synthesizing buprofezin

The invention discloses a method for continuously synthesizing buprofezin, and belongs to the technical field of chemical synthesis. The method for continuously synthesizing buprofezin comprises the following steps: S1, continuously acylating N-methylaniline and phosgene in a solvent, and continuously deacidifying to obtain an acyl chloride solution; S2, carrying out continuous chlorination and continuous deacidification on the acyl chloride solution and chlorine under the action of an initiator to obtain a chloride solution; S3, adding buprothiourea, a catalyst and an acid-binding agent intothe chloride solution, carrying out continuous mixing reaction, crystallizing and drying a reaction product to obtain buprofezin of which the content is greater than or equal to 99.0% and the total yield is greater than or equal to 88% based on N-methylaniline. The method for continuously synthesizing buprofezin solves the defects caused by batch production in China, has the advantages of continuous reaction, high automation degree, small equipment size, high operation safety, few side reaction products, high conversion rate and good product quality, can effectively improve the production efficiency and reduce the production cost, and has very good popularization and application values.

Synthesis method of buprofezin

The invention provides a synthesis method of buprofezin. The synthesis method comprises the following step: carrying out a cyclization reaction on raw materials including N-chloromethyl-N-phenylaminoformyl chloride and N-tert-butyl-N'-isopropylthiourea, wherein an acid binding agent takes acetate as a main component. According to the synthesis method provided by the invention, sodium acetate is adopted to replace ammonium bicarbonate and is used as alkali needed for synthesizing the buprofezin; the problem that solvent loss is caused by the release of carbon dioxide generated in a process of synthesizing a product through the ammonium bicarbonate is solved, and a byproduct, namely sodium chloride, can be directly filtered and removed and can be recycled to obtain certain economic benefit;meanwhile, energy consumption generated by wastewater treatment is reduced and zero emission of wastewater is realized; the average yield of the buprofezin prepared by adopting the synthesis method provided by the invention reaches 86 percent or more, and the content of the finished-product buprofezin reaches 97.0 percent or more.

Preparation method of buprofezin

The invention provides a preparation method of buprofezin, comprising the steps of 1), adding sodium thiocyanate and water into an esterification kettle until dissolution; adding tertiary butanol andhydrochloric acid to obtain a mixed ester; allowing transposition and catalytic reaction to obtain t-butyl isothiocyanate; 2), adding the t-butyl isothiocyanate into chlorobenzene, stirring, dropwiseadding isopropyl amine to obtain 1-isopropyl-3-tert-butylthiourea solution; 3), adding N-methylaniline into chlorobenzene; introducing carbonyl chloride and chlorine gas in sequence to obtain N-chloromethyl-N-benzenecarbamoylchloride solution; 4), adding sodium bicarbonate into water, and adding the resultant into chlorobenzene; adding the 1-isopropyl-3-tert-butylthiourea solution; dropwise addingthe N-chloromethyl-N-benzenecarbamoylchloride solution, filtering, allowing layering, performing high-vacuum steaming to remove the chlorobenzene, crystallizing, centrifuging, and drying to obtain buprofezin. The substitutive average yield of the preparation process of buprofezin reaches 90% and above; the content of finished buprofezin reaches 98.0% and above; the preparation process is free ofammonia nitrogen wastewater.

Buprofenzin process for the preparation of

The invention relates to a preparation method of buprofezin, which comprises the following steps of actinism, chlorination, synthesis and distillation crystallization. The actinism step employs dioxane or chloroform, the chlorination step employs dioxane or N-chloromethyl-N-phenyl carbamyl chloride as a solvent; and the synthesis step employs organic amine to participate in condensation. According to the invention, dioxane, chloroform or N-chloromethyl-N-phenyl carbamyl chloride are employed as the solvents, so that good dissolving performance is provided to the raw material, and the dioxane, chloroform or N-chloromethyl-N-phenyl carbamyl chloride has little solubility to HCL and is in favor of reaction, the production yield can reach as high as more than 82%; organic amine is employed for replacing ammonium bicarbonate as alkali for synthesis reaction, and can be recovered so that the discharge of ammonia nitrogen in waste water is reduced.

Active agent combinations

The novel active compound combinations of extracts from seeds of the neem tree and the active compounds of groups (B) to (F) listed in the description have very good insecticidal and acaricidal properties.

PESTICIDAL COMPOSITIONS

Composition for controlling insects and representatives of the order Acarina, which comprises a combination of variable amounts of one or more compounds of the formula in which A is an unsubstituted or, depending on the possibility of substitution on the ring system, mono- to tetrasubstituted, aromatic or non-aromatic monocyclic or bicyclic heterocyclic radical, in which the substituents of A can be chosen from the group consisting of C1-C3alkyl, C1-C3alkoxy, halogen, halo-C1-C3alkyl, cyclopropyl, halocyclopropyl, C2-C3alkenyl, C2-C3alkynyl, halo-C2-C3alkenyl, halo-C2-C3alkynyl, halo-C1-C3alkoxy, C1-C3alkylthio, Halo-C1-C3alkylthio, allyloxy, propargyloxy, allylthio, propargylthio, haloallyloxy, haloallylthio, cyano and nitro; R is hydrogen, C1-C6alkyl, phenyl-C1-C4alkyl, C3-C6cycloalkyl, C2-C6alkenyl or C2-C6alkynyl; and X is N—NO2 or N—CN, in the free form or in salt form, if appropriate tautomers, in the free form or salt form, and one or more of the compounds (I) to (CLXXXIV) mentioned according to the invention and at least one auxiliary. A method of controlling pests, a process for the preparation of the composition, its use and plant propagation material treated with it, and the use of the compound of the formula (A) for the preparation of the composition, are described.

S-(N-alkoxycarbonyl, N-substituted)aminomethyl isothiourea derivative

S-(N-alkoxycarbonyl, N-substituted)amino methyl isothiourea derivative, which is a useful intermediate for the production of 1,3,5-thiadiazine-4-one derivative, is disclosed. The above compound can be produced by reacting the carbamate compound of the formula(II) with the thiourea compound of the formula(III).

S-(N-alkoxycarbonyl, N-substituted) amino-methyl isothiourea derivative

A S-(-N-alkoxycarbonyl, N-substituted)amino methyl isothiourea derivative of the formula: wherein, each of R1, R2, R3, R4, R5 and R6, which may be the same or different, represents an alkyl group, an alkenyl group, an alkynyl group, a haloalkynyl group, a haloalkenyl group, a haloalkylnyl group, an alkoxyalkyl group, a cycloalkyl group, a cycloalkenyl group, an aryl group, a substituted-aryl group, an aralkyl group, a substituted-aralkyl group, a naphtyl, a pyridyl, (wherein each of X1, X2 and X3, which may be the same or different, represents a hydrogen atom, an alkyl group, a cycloalkyl group, an alkoxy group, an acetyl, a haloalkyl group, a halogen atom, CF3, NO2, hydroxy, a benzyl, phenyl, a phenoxy or phenylthio group) or (wherein each of Y1 and Y2, which may be the same or different, represents a hydrogen atom, a lowered alkyl group, a halogen atom, CF3, a lowered alkoxy group, W represents a group, {in which each of R7 and R8 represents a hydrogen atom or a lowered alkyl group}, -O- group. a , - n- (wherein n is an integer of 2 to 4), -CH2-O-CH2- or -CH2-S-CH2- ; provided, however, that at least one of R4, R5 and R6 is a hydrogen atom, is disclosed. This is a useful intermediate for the production of 1,3,5-thiadiazine-4-one derivatives.

Tetrahydro-1,3,5-thiadiazin-4-one derivative

A tetrahydro-1,3,5-thiadiazin-4-one represented by the general formula, STR1 wherein R1, R2 and R3, which may be the same or different, represent each an alkyl group, allyl group, cycloalkyl group, alkoxyalkyl group, benzyl group, phenyl group or substituted phenyl group having as substituents alkyl groups, nitro group, halogen atoms, alkoxy groups, or trifluoromethyl group and R2 and R3 may also represent hydrogen atoms, is a new compound and useful for controlling insects and mites.