95332-25-5Relevant academic research and scientific papers
A facile Ph3P/CO2 mediated, one-pot synthesis of 2-oxazolidinones from 1, 2-azido alcohols via phosphazene and isocyanate intermediates
Madhusudhan,Reddy, M. Srinivasa,Reddy, Y. Narayana,Vijayalakshmi,Suribabu,Balraju
body text, p. 978 - 984 (2010/10/19)
A facile, efficient and convenient method has been developed for the one-pot synthesis of 2-oxazolidinones from the corresponding 1, 2-azido alcohols via phosphazene and isocyanate intermediates in presence of Ph 3P/CO2 in toluene.
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARα/γ agonists. Part I: Synthesis and pharmacological evaluation
Parmenon, Cecile,Guillard, Jerome,Caignard, Daniel-Henri,Hennuyer, Nathalie,Staels, Bart,Audinot-Bouchez, Valerie,Boutin, Jean-Albert,Dacquet, Catherine,Ktorza, Alain,Viaud-Massuard, Marie-Claude
, p. 1617 - 1622 (2008/09/19)
Type-2 diabetes (T2D) is a complex metabolic disease characterized by insulin resistance in the liver and peripheral tissues accompanied by a defect in pancreatic β-cell. Since their discovery three subtypes of Peroxisomes Proliferators Activated Receptors were identified namely PPARα, PPARγ and PPARβ/(δ). We were interested in designing novel PPARγ selective agonists and/or dual PPARα/γ agonists. Based on the typical topology of synthetic PPAR agonists, we focused our design approach on 4,4-dimethyl-1,2,3,4-tetrahydroquinoline as novel cyclic tail.
Studies on synthesis and anti-bacterial activity of novel 4-substituted phenyl-2-oxo-1,3-oxazolidine-5-carboxylates
Madhusudha,Om Reddy,Ramatham,Dubey
, p. 957 - 963 (2007/10/03)
Regioselective opening of glycidic esters with sodium azide gives azido alcohols, which are converted to novel 4-substituted phenyl-2-oxo-1, 3-oxazolidine-5-carboxylates by various methods. These compounds are tested for in vitro anti-bacterial activity against Staphylococcus aureous, E. faecalis and E. faecium.
