95333-95-2

Usage

Uses

3-(3,5-Dichloro-phenyl)-propionic acid

InChI:InChI=1/C9H8Cl2O2/c10-7-3-6(1-2-9(12)13)4-8(11)5-7/h3-5H,1-2H2,(H,12,13)

Upstream product

• 20595-53-3 3-(3,5-dichlorophenyl)-2-propenoic acid 
• 923977-11-1 5-(3,5-dichloro-benzyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 20595-54-4 3,5-dichloro-cis-cinnamic acid 

Downstream Products

• 95333-96-3 3-(3,5-dichlorophenyl)-propanol 
• 1021165-99-0 tert-butyl 3-(3,5-dichlorophenyl)propanoate 

Relevant academic research and scientific papers

BENZENE FUSED HETEROCYCLIC COMPOUND AND USE THEREOF

The present disclosure provides a benzene fused heterocyclic compound of Formula (I): wherein (A) is a single or double bond; n is 0 or 1; X is -CH2-, O, NR1, or S; A is -C(Ra1)(Ra2)(Ra3) or -N(R

Efficient synthesis of halo indanones via chlorosulfonic acid mediated Friedel-Crafts cyclization of aryl propionic acids and their use in alkylation reactions

Several halo indanones were synthesized from benzyl Meldrum's acid derivatives in two steps. Although several Lewis acids are effective for the Friedel-Crafts ring-closing reaction on more electron-rich arenes, in the case of the electron-deficient arenes this chemistry is not efficient. Here it is reported that chlorosulfonic acid (used as solvent) is an efficient reagent for cyclization of electron-withdrawing arenes. These molecules are potentially useful for subsequent alkylation reactions. The selective alkylation of 5,7-dibromo indanone is demonstrated using Pd-catalyzed Grignard coupling to provide monoalkylated indanone in good yield.

Indanylidenes. 2. Design and synthesis of (E)-2-(4-chloro-6-fluoro-1-indanylidene)-N-methylacetamide, a potent antiinflammatory and analgesic agent without centrally acting muscle relaxant activity

Extension of the structure-activity relationship studies that led to the discovery of the nonsedating potent muscle relaxant, antiinflammatory, and analgesic agent (E)-2-(4,6-difluoro-1-indanylidene)acetamide, 1, has given rise to (E)-2-(4-chloro-6-fluoro

Method for treating glaucoma

Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.

Prevention of loss and restoration of bone mass by certain prostaglandin agonists

Prostaglandin agonists of formula (I), in which, for example, A is a sulphonyl or acyl group, B is N or CH, M contains a ring and K and Q are linking groups, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits useful for the treatment of bone disorders including osteoporosis. STR1

DOPAMINE-BETA-HYDROXYLASE INHIBITORS

Potent DBH inhibitors having the formula can be used to inhibit DBH activity in mammals.

Dopamine-β-hydroxylase inhibitors and use thereof

The compounds of this invention are 1-phenylalkyl-2-mercaptotetrazole compounds which are dopamine-β-hydroxylase inhibitors.