953395-23-8

Basic information

• Product Name: (S)-N-(2-(2-hydroxypropyl)phenyl)-4-methylbenzenesulfonamide
• Synonyms: (S)-N-(2-(2-hydroxypropyl)phenyl)-4-methylbenzenesulfonamide
• CAS NO: 953395-23-8
• Molecular Weight: 305.398
• Mol File: 953395-23-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-N-(2-(2-hydroxypropyl)phenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-(2-(2-hydroxypropyl)phenyl)-4-methylbenzenesulfonamide(953395-23-8)
• EPA Substance Registry System: (S)-N-(2-(2-hydroxypropyl)phenyl)-4-methylbenzenesulfonamide(953395-23-8)

Safety Data

• Hazardous Substances Data: 953395-23-8(Hazardous Substances Data)

Upstream product

• 615-36-1 2-bromoaniline 
• 1024-38-0 N-(2-bromophenyl)-4-methylbenzenesulfonamide 
• 16088-62-3 (S)-Propylene oxide 
• 98-59-9 p-toluenesulfonyl chloride 
• 953395-21-6 (2S)-1-[2-(4-methylphenylsulfonamido)phenyl]-2-propanyl 3-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]acetate 

Downstream Products

• 953395-24-9 (S)-1-(2-(4-methylphenylsulfonamido)phenyl)-2-propanyl 4-pentynoate 
• 953395-26-1 (S)-1-(2-(4-methylphenylsulfonamido)phenyl)-2-propanyl 2-ethynylbenzoate 

Relevant articles and documents

Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides

The direct, catalytic substitution of unactivated alcohols remains an undeveloped area of organic synthesis. Moreover, catalytic activation of this difficult electrophile with predictable stereo-outcomes presents an even more formidable challenge. Described herein is a simple iron-based catalyst system which provides the mild, direct conversion of secondary and tertiary alcohols to sulfonamides. Starting from enantioenriched alcohols, the intramolecular variant proceeds with stereoinversion to produce enantioenriched 2- and 2,2-subsituted pyrrolidines and indolines, without prior derivatization of the alcohol or solvolytic conditions.