953398-68-0Relevant academic research and scientific papers
Synthetic staurosporines via a ring closing metathesis strategy as potent JAK3 inhibitors and modulators of allergic responses
Wilson, Lawrence J.,Malaviya, Ravi,Yang, Cangming,Argentieri, Rochelle,Wang, Bingbing,Chen, Xin,Murray, William V.,Cavender, Druie
, p. 3333 - 3338 (2009)
The synthesis and biological evaluation of JAK3 based staurosporine compounds is described. The compounds are constructed completely de novo, and a ring closing metathesis strategy is used to assemble the sugar mimetic portion. These analogs show potent J
