953422-34-9Relevant academic research and scientific papers
A novel use of the recyclable polymer-supported IBX: an efficient chemoselective and regioselective oxidation of phenolic compounds. The case of hydroxytyrosol derivatives.
Bernini, Roberta,Mincione, Enrico,Crisante, Fernanda,Barontini, Maurizio,Fabrizi, Giancarlo
, p. 1307 - 1310 (2009)
A useful and novel application of polymer-supported IBX for the chemoselective and regioselective oxidation of phenolic compounds has been described. Hydroxytyrosol and carboxymethylated hydroxytyrosol have been prepared in good conversions and yields und
Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells
Bernini, Roberta,Crisante, Fernanda,Merendino, Nicol,Molinari, Romina,Soldatelli, Maria Chiara,Velotti, Francesca
experimental part, p. 439 - 446 (2011/02/25)
A novel ester of hydroxytyrosol and α-lipoic acid was synthesized in satisfactory yield by original and simple procedures and evaluated about its antiproliferative activity on the human colorectal adenocarcinoma HT-29 cell line. The compound exhibited a cell growth inhibitory activity significantly more potent than the corresponding parent natural compounds, very likely due to the induction of cell cycle arrest in the G2/M phase. These data suggest that the novel ester might exert a more effective antitumour activity than hydroxytyrosol and α-lipoic acid.
METHOD FOR PREPARING HYDROXYTYROSOL DERIVATIVES AND OF HYDROXYTYROSOL
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Page/Page column 11-12, (2008/12/07)
The present invention concerns a method for preparing hydroxytyrosol derivatives of general formula (III), where R=OCH3, or CF3 or an alkylic saturated or unsaturated, straight or cyclic, branched or not branched, chain from 1 to 31 carbon atoms, and for the preparation of hydroxytyrosol (IV).
2-Arylhydroxytyrosol derivatives via Suzuki-Miyaura cross-coupling
Bernini, Roberta,Cacchi, Sandro,Fabrizi, Giancarlo,Filisti, Eleonora
body text, p. 3457 - 3460 (2009/05/07)
(Chemical Equation Presented) 2-Arylhydroxytyrosol derivatives, a new class of hydroxytyrosol derivatives, have been prepared in high to excellent yields from the corresponding 2-chloro precursors via Suzuki-Miyaura cross-coupling with arylboronic acids c
Chemoselective and efficient carbomethoxylation of the alcoholic chain of phenols by dimethyl carbonate (DMC)
Bernini, Roberta,Mincione, Enrico,Crisante, Fernanda,Barontini, Maurizio,Fabrizi, Giancarlo,Gentili, Patrizia
, p. 7000 - 7003 (2008/03/12)
The efficiency of dimethyl carbonate (DMC) as chemoselective carbomethoxylating agent of the alcoholic chain of phenols has been investigated. In the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) or sulfuric acid as catalysts, new carbomethoxylated
