953423-53-5

Upstream product

• 870650-02-5 ethyl 2-{(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-[(benzyloxy)methyl]-tetrahydro-2-hydroxy-2H-pyran-2-yl}-2,2-difluoroacetate 

Downstream Products

• 953423-67-1 C₅₉H₅₉F₂NO₁₄ 
• 953423-55-7 C₅₈H₅₇F₂NO₁₄ 
• 953423-54-6 C₅₇H₅₅F₂NO₁₄ 

Relevant academic research and scientific papers

NOVEL GEM-DIFLUORINATED C-GLYCOSIDE COMPOUNDS DERIVED FROM PODOPHYLLOTOXIN, THEIR PREPARATION AND THEIR APPLICATIONS

The invention relates to a gem-difluoride glycoconjugated compound with formula (I): where R represents II or a benzyl, acetyl, benzoyl alkyl group, R1 and R2 may be identical or different and represent H or an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl, tertiobutyldiphenylsilyl protective group or an acetal group of the CR′R′ type, where R′ and R′ may be identical or different and represent H or an alkyl, aryl, benzyl or thiophene group, R3 represents H or an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl or tertiobutyldiphenylsilyl protective group, R4 represents OR″, NGR′GR′, N3, or a phthalimide, where R″ represents H or an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl or tertiobutyldiphenylsilyl protective group, GR′ and GR′ may be identical or different and represent II or an alkyl, benzyl, benzoyl, acetyl, alkyloxycarbonyl, allyloxycarbonyl or benzyloxycarbonyl group, R5 represents a free or protected hydroxyl group or a halogen, R6 represents H or an alkyl, acetyl, benzyl, PO3H or PO3Na group. It is applicable to the preparation of compounds that can be used particularly for the treatment of cancer.

Novel difluorinated gem compounds, preparation methods thereof and applications of same

This invention relates to a mini-type electric vehicle, which is mainly used for individual person or traffic in a certain field. It includes frame, seat, front and rear wheel, driving device, battery, steering system and front wheel suspension device. A casing, where the battery is placed on, protrudes forward at the middle position of the front end of the frame; the suspension device for front wheel appears “Front convex and rear concave” shape and covers the front end of that casing, and pivots to the middle of the front end of the casing. Two front wheels are installed on the front wheel suspension device. The rear edge line of the two front wheels is located at the rear of the battery front edge; Steering system is connected to the front end of the frame and interlocks with the front wheel. Battery is installed at the front so as to balance the weight distribution, improve the driving safety, comfort and steering performance for electric vehicle.