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CAS

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953425-38-2

N-2-(1H-indol-3-yl)-2-oxoethyl-2-(3,4,5-trimethoxyphenyl)acetamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 953425-38-2 Structure

  • Basic information

    1. Product Name: N-2-(1H-indol-3-yl)-2-oxoethyl-2-(3,4,5-trimethoxyphenyl)acetamide
    2. Synonyms: N-2-(1H-indol-3-yl)-2-oxoethyl-2-(3,4,5-trimethoxyphenyl)acetamide
    3. CAS NO:953425-38-2
    4. Molecular Formula:
    5. Molecular Weight: 382.416
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 953425-38-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-2-(1H-indol-3-yl)-2-oxoethyl-2-(3,4,5-trimethoxyphenyl)acetamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-2-(1H-indol-3-yl)-2-oxoethyl-2-(3,4,5-trimethoxyphenyl)acetamide(953425-38-2)
    11. EPA Substance Registry System: N-2-(1H-indol-3-yl)-2-oxoethyl-2-(3,4,5-trimethoxyphenyl)acetamide(953425-38-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 953425-38-2(Hazardous Substances Data)

953425-38-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 953425-38-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,3,4,2 and 5 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 953425-38:
(8*9)+(7*5)+(6*3)+(5*4)+(4*2)+(3*5)+(2*3)+(1*8)=182
182 % 10 = 2
So 953425-38-2 is a valid CAS Registry Number.

953425-38-2Relevant articles and documents

Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole- 3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors

Peifer, Christian,Selig, Roland,Kinkel, Katrin,Ott, Dimitri,Totzke, Frank,Sch?chtele, Christoph,Heidenreich, Regina,R?cken, Martin,Schollmeyer, Dieter,Laufer, Stefan

supporting information; experimental part, p. 3814 - 3824 (2009/05/11)

In this study we report on the design, synthesis, and biological evaluation of pyrrole-2-one 2 to be a highly potent VEGF-R2/3 inhibitor with IC 50 of 31/37 nM. The novel 3,4-diaryl-2H-pyrrole-2-ones were designed on the basis of the modeled binding mode of the corresponding 1H-pyrrole-2,5-dione (maleimide) VEGF-R2/3 inhibitor 1 indicating two H-bond ligand-protein interactions in the ATP pocket for the amide 2 but not for the isomer 3. Flexible synthetic routes to 3,4-diaryl-2//-pyrrole-2-ones and structure-activity relationships for the compounds in a panel of 24 therapeutically relevant protein kinases (IC50 values) are presented. Accordingly to the in vitro data, compounds 1 and 2 were found to possess highly potent antiangiogenic activities in the cellular HLMEC sprouting assay and also slightly induced apoptosis in HDMECs whereas 3 was determined to be significantly less active. Hence, the pyrrole-2-one moiety was dissected from the corresponding maleimide protein kinase inhibitor as a suitable key pharmacophore.

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