95356-15-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(O-Tolyl)piperazine hydrochloride is used as a building block for the synthesis of various pharmaceutical drugs, particularly in the preparation of antihistamines and antipsychotics. Its central nervous system stimulant properties make it a valuable component in the development of these medications.
Used in Antihistamine Preparation:
1-(O-Tolyl)piperazine hydrochloride is used as an active ingredient in antihistamines for its ability to counteract the effects of histamine, a compound involved in allergic reactions. This application helps in reducing symptoms such as itching, redness, and swelling associated with allergies.
Used in Antipsychotic Medication:
1-(O-Tolyl)piperazine hydrochloride is used as a component in antipsychotic medications to help manage the symptoms of psychotic disorders, such as schizophrenia and bipolar disorder. Its psychoactive properties contribute to the regulation of neurotransmitters in the brain, aiding in the control of hallucinations, delusions, and disordered thoughts.
Used in Psychoactive Substance Research:
1-(O-Tolyl)piperazine hydrochloride is used as a subject of research for its potential as a psychoactive substance. Studies aim to understand its effects on the central nervous system and explore its possible therapeutic applications in the treatment of various mental health conditions.
Used in Pharmaceutical Formulations:
Due to its water-solubility and stability, 1-(O-Tolyl)piperazine hydrochloride is used in the formulation of pharmaceutical products, ensuring the effective delivery of the active ingredients to the target site in the body. This property is crucial for the development of safe and efficacious medications.

Upstream product

• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 95-53-4 o-toluidine 

Downstream Products

• 478179-08-7 2,4-bis-(2-hydroxy-ethylamino)-6-(4-o-tolyl-piperazin-1-yl)-pyrimidine-5-carbonitrile 
• 1159928-99-0 2-(4-methylpiperazin-1-yl)ethyl 4-(2-methylphenyl)piperazine-1-carboxylate 
• 1253909-17-9 4-methyl-3-[4-(2,2,2-trifluoro-acetyl)-piperazin-1-yl]-benzenesulfonyl chloride 
• 1374743-28-8 N-(3-methoxymethyl-phenyl)-4-methyl-3-piperazin-1-yl-benzenesulfonamide 
• 1374643-76-1 4-methyl-N-(3-methoxymethyl-phenyl)-3-[4-(2,2,2-trifluoro-acetyl)-piperazin-1-yl]benzenesulfonamide 
• 108582-86-1 2-<5-(4-(o-tolyl)piperazin-1-yl-methyl)-2-(1H-indol-3-yl)-4-oxo-3-thiazolidinyl>-9,10-anthracenedione hydrochloride 
• 124617-56-7 1-Benzofuran-2-yl-3-(4-o-tolyl-piperazin-1-yl)-propan-1-ol; hydrochloride 
• 68788-72-7 5-[2-hydroxy-3-(4-o-tolyl-1-piperazinyl)]propoxy-8-methanesulfonylamino-3,4-dihydrocarbostyril hydrochloride 
• 1542226-04-9 1-(2-(4-bromophenoxy)ethoxy)-3-(4-(o-tolyl)piperazin-1-yl)propan-2-ol 
• 39512-51-1 1-(o-toluyl)piperazine 
• 1343457-64-6 6-fluoro-3,3-dimethyl-2-[3-(4-o-tolyl-piperazin-1-yl)-phenyl]-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid 
• 1252617-49-4 4-[4-(2-methylphenyl)piperazine]butyronitrile 
• 1447363-95-2 2-methyl-5-nitro-4-(4-o-tolylpiperazin-1-yl)benzoic acid 
• 1403353-54-7 C₁₈H₁₉N₅O 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands

Two series of hybrid analogues were designed, synthesized, and evaluated as a novel class of selective ligands for the dopamine D3 receptor. Binding affinities of target compounds were determined (using the method of radioligand binding assay). Compared to comparator agent BP897, compounds 2a and 2c were found to demonstrate a considerable binding affinity and selectivity for D3 receptor, and especially compound 2h was similarly potent and more selective D3R ligand than BP897, a positive reference. Thus, they may provide valuable information for the discovery and development of highly potent dopamine D3 receptor ligands with outstanding selectivity.

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold

Previously, we identified 1-(2-(4-bromophenoxy)ethoxy)-3-(4-(2- methoxyphenyl)piperazin-1-yl)propan-2-ol (1) as a novel Hsp90 inhibitor with moderate activity through virtual screening. In this study, we report the optimization process of 1. A series of analogues containing the 1-phenylpiperazine core scaffold were synthesized and evaluated. The structure-activity relationships (SAR) for these compounds was also discussed for further molecular design. This effort afforded the most active inhibitor 13f with improved activity in not only target-based level, but also cell-based level compared with the original hit 1.