95361-36-7Relevant academic research and scientific papers
Solvent treatment method in chlorination technique in GCLE (7-phenylacetamido-3-cephem-4-carboxylic p-methoxybenzyl ester) synthesis process
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Paragraph 0013; 0014, (2017/02/09)
The invention provides a solvent treatment method in a chlorination technique in a GCLE (7-phenylacetamido-3-cephem-4-carboxylic p-methoxybenzyl ester) synthesis process. The method specifically comprises the following operation steps: putting a solvent t
PROCESS FOR PRODUCING 3-CHLOROMETHYL-3-CEPHEM DERIVATIVE
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Page/Page column 15-16; 19-20, (2008/06/13)
An industrially advantageous process for producing 3-chloromethyl-3-cephem derivative crystals. The process for 3-chloromethyl-3-cephem derivative production comprises: a first step in which a thiazolineazetidinone derivative (1) is reacted with a sulfonyl halide (2) in the presence of an acid in a solvent to obtain an azetidinone derivative (3); a second step in which the azetidinone derivative (3) is reacted with a chlorinating agent in an organic solvent to obtain a chlorinated azetidinone derivative (4); and a third step in which the chlorinated azetidinone derivative (4) is reacted with an alcoholate (5) at a pH of 8 or lower in a solvent comprising an alcohol and an ether and a 3-chloromethyl-3-cephem derivative (6) is recovered in the form of crystals.
