95365-88-1

Basic information

• Product Name: cis-10-(3-Dimethylamino-propyliden)-2-trifluormethyl-thiaxanthen
• Synonyms: cis-10-(3-Dimethylamino-propyliden)-2-trifluormethyl-thiaxanthen
• CAS NO: 95365-88-1
• Molecular Weight: 349.42
• Mol File: 95365-88-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: cis-10-(3-Dimethylamino-propyliden)-2-trifluormethyl-thiaxanthen(CAS DataBase Reference)
• NIST Chemistry Reference: cis-10-(3-Dimethylamino-propyliden)-2-trifluormethyl-thiaxanthen(95365-88-1)
• EPA Substance Registry System: cis-10-(3-Dimethylamino-propyliden)-2-trifluormethyl-thiaxanthen(95365-88-1)

Safety Data

• Hazardous Substances Data: 95365-88-1(Hazardous Substances Data)

Upstream product

• 2340-57-0 (9RS)-9-[3-dimethylamino-propyl]-2-(trifluoromethyl)-9H-thioxanthene-9-ol 

Downstream Products

• 2709-56-0 2-{4-[3-(2-trifluoromethyl-thioxanthen-9-ylidene)-propyl]-piperazin-1-yl}-ethanol 

Relevant articles and documents

A hydrochloric acid flupentixol preparation method

The invention provides a preparation method of flupentixol dihydrochloride, which comprises the following steps: reacting and dehydrating 10-hydroxy-10-(3-dimethylaminopropyl)-2-trifluoromethyl thioxanthene and sulfoxide chloride or acetic anhydride to prepare high-content Z-type 10-[3-(EZ)-dimethylaminopropyl]-2-trifluoromethyl thioxanthene, reacting with N-hydroxyethyl piperazidine to prepare flupentixol base, and finally, introducing sufficient hydrochloric acid gas into the flupentixol base to prepare the high-content Z-type flupentixol dihydrochloride. The method has the advantages of fewer steps, high yield and high product purity, is simple to operate, and does not use any extremely toxic substance to pollute the environment. The Z-type flupentixol dihydrochloride content in the flupentixol dihydrochloride prepared by the method is 42-52%, and conforms to the quality standard specification for flupentixol dihydrochloride in European Pharmacopoeia.