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953730-41-1

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953730-41-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 953730-41-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,3,7,3 and 0 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 953730-41:
(8*9)+(7*5)+(6*3)+(5*7)+(4*3)+(3*0)+(2*4)+(1*1)=181
181 % 10 = 1
So 953730-41-1 is a valid CAS Registry Number.

953730-41-1Downstream Products

953730-41-1Relevant articles and documents

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

Flaherty, Daniel P.,Simpson, Denise S.,Miller, Melissa,Maki, Brooks E.,Zou, Beiyan,Shi, Jie,Wu, Meng,McManus, Owen B.,Aubé, Jeffrey,Li, Min,Golden, Jennifer E.

, p. 3968 - 3973 (2014/09/03)

TASK-1 is a two-pore domain potassium channel that is important to modulating cell excitability, most notably in the context of neuronal pathways. In order to leverage TASK-1 for therapeutic benefit, its physiological role needs better characterization; however, designing selective inhibitors that avoid the closely related TASK-3 channel has been challenging. In this study, a series of bis-amide derived compounds were found to demonstrate improved TASK-1 selectivity over TASK-3 compared to reported inhibitors. Optimization of a marginally selective hit led to analog 35 which displays a TASK-1 IC 50 = 16 nM with 62-fold selectivity over TASK-3 in an orthogonal electrophysiology assay.

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