Basic information

Product Name: 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide
Synonyms: 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide;BLZ945;4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide BLZ945;4-[[2-[[(1R,2R)-2-Hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl-2-pyridinecarboxamide;BLZ-945 >=95%
CAS NO:953769-46-5
Molecular Formula: C20H22N4O3S
Molecular Weight: 398.47868
EINECS: N/A
Product Categories: Inhibitors
Mol File: 953769-46-5.mol

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: /
Density: 1.377±0.06 g/cm3(Predicted)
Refractive Index: N/A
Storage Temp.: N/A
Solubility: insoluble in EtOH; insoluble in H2O; ≥19.9 mg/mL in DMSO
PKA: 13.92±0.46(Predicted)
CAS DataBase Reference: 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide(CAS DataBase Reference)
NIST Chemistry Reference: 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide(953769-46-5)
EPA Substance Registry System: 4-((2-(((1R,2R)-2-hydroxycyclohexyl)aMino)benzo[d]thiazol-6-yl)oxy)-N-MethylpicolinaMide(953769-46-5)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 953769-46-5(Hazardous Substances Data)

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SDS
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953769-46-5 Usage

Uses

Used in Pharmaceutical Industry:
BLZ945 is used as a tumor-associated macrophage targeting agent for the treatment of glioblastoma multiforme, the most common and aggressive type of brain cancer. Its unique structure allows it to selectively target and modulate the activity of tumor-associated macrophages, which play a crucial role in tumor progression and resistance to therapy. By targeting these macrophages, BLZ945 has the potential to enhance the efficacy of conventional cancer treatments and improve patient outcomes.
In addition to its primary application in glioblastoma treatment, the unique structure and properties of BLZ945 may also make it a promising candidate for other therapeutic applications. Its ability to modulate the activity of immune cells, such as macrophages, could potentially be harnessed to treat other types of cancer or inflammatory diseases. Further research and development are needed to fully explore the potential applications of this novel compound.

Check Digit Verification of cas no

The CAS Registry Mumber 953769-46-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,3,7,6 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 953769-46:
(8*9)+(7*5)+(6*3)+(5*7)+(4*6)+(3*9)+(2*4)+(1*6)=225
225 % 10 = 5
So 953769-46-5 is a valid CAS Registry Number.

953769-46-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide

1.2 Other means of identification

Product number	-
Other names	BLZ-945

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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