953781-86-7Relevant academic research and scientific papers
Mechanistic Investigation of Castagnoli-Cushman Multicomponent Reactions Leading to a Three-Component Synthesis of Dihydroisoquinolones
Howard, Sara Y.,Di Maso, Michael J.,Shimabukuro, Kristin,Burlow, Noah P.,Tan, Darlene Q.,Fettinger, James C.,Malig, Thomas C.,Hein, Jason E.,Shaw, Jared T.
supporting information, p. 11599 - 11607 (2021/09/02)
The mechanisms for the three- and four-component variants of the Castagnoli-Cushman reaction (CCR) have been investigated. A series of crossover experiments were conducted to probe the structure and reactivity of known amide-acid intermediates for the thr
Diastereoselective synthesis of γ-lactams by a one-pot, four-component reaction
Jingqiang, Wei,Shaw, Jared T.
, p. 4077 - 4080 (2008/02/11)
A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra-and pentasubstituted γ-lactams with high diastereoselectivity. Each component is independently variable and employed in
