953802-69-2Relevant academic research and scientific papers
3-Amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile
Scott, David A.,Bell, Kirsten J.,Campbell, Cheryl T.,Cook, Donald J.,Dakin, Les A.,Del Valle, David J.,Drew, Lisa,Gero, Thomas W.,Hattersley, Maureen M.,Omer, Charles A.,Tyurin, Boris,Zheng, Xiaolan
scheme or table, p. 701 - 705 (2009/08/15)
The optimization of compounds from the 3-amido-4-anilinoquinolines series of CSF-1R kinase inhibitors is described. The series has excellent activity and kinase selectivity. Excellent physical properties and rodent PK profiles were achieved through the introduction of cyclic amines at the quinoline 6-position. Compounds with good activity in a mouse PD model measuring inhibition of pCSF-1R were identified.
4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS
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Page/Page column 102, (2008/06/13)
The invention relates to chemical compounds of formula IA or IB: formula IA IB or pharmaceutically acceptable salts thereof which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of tr
