953817-46-4Relevant articles and documents
Synthesis of novel 1-pyrazolylpyridin-2-ones as potential anti-inflammatory and analgesic agents
Ismail, Magda M. F.,Ammar, Yousry A.,El-Zahaby, Heba S. A.,Eisa, Sally I.,Barakat, Saber El-Sayed
, p. 476 - 482 (2008/12/21)
A new series of 4-alkyl/aryl-2-oxo-1-pyrazolyl-1,2-dihydropyridine-3- carbonitriles, pyrazolo[3,4-b]pyridine-5-carbonitriles and pyrido[2,3-d] pyrimidine-6-carbonitriles have been synthesized and tested for their anti-inflammatory and analgesic activities. Among the tested compounds, 3e and 8b exhibited comparable anti-inflammatory activity to the standard (indomethacin). Compounds 5, 7a, and 8b displayed potent analgesic activity. Detailed syntheses, spectroscopic and biological data are reported.