95403-16-0Relevant academic research and scientific papers
6,8-Di-C-methyl-flavonoids with neuroprotective activities from Rhododendron fortunei
Lai, Yongji,Zeng, Hong,He, Meijun,Qian, Huiqin,Wu, Zhaodi,Luo, Zengwei,Xue, Yongbo,Yao, Guangmin,Zhang, Yonghui
, p. 237 - 243 (2016/07/06)
Six 6,8-di-C-methyl-flavonoids, (2R,3R)-6,8-di-C-methyl-5,7,4′-trihydroxyflavanonol 7-O-β-D-gluco-pyranoside (1), (2R,3R)-6,8-di-C-methyl-5,7,4′-trihydroxyflavanonol 7-O-β-D-xylopyranosyl(1?→?6)-β-D-glucopyranoside (2), 6,8-di-C-methylkaempferol 7-O-β-D-glucopyranoside (3), (2R)-farrerol (4a), (2R/2S)-farrerol 7-O-β-D-glucopyranoside (5), and (2R/2S)-farrerol 7-O-β-D-xylopyranosyl(1?→?6)-β-D-glucopyranoside (6), and four known analogues, farrerol (4b), (2R,3R)-6,8-di-C-methyldihydrokae-mpferol (7), 6,8-di-C-methylkaempferol 7-O-β-D-glucopyranoside (8), and 6,8-di-C-methylkaempferol (9), were isolated from the twigs and leaves of Rhododendron fortunei. The structures of compounds 1–9 were determined by spectroscopic analyses (HRESIMS, 1D and 2D NMR, and CD) and chemical methods. Compounds 1–9 were evaluated for their neuroprotective effects on the human neuroblastoma SH-SY5Y cells apoptosis induced by hydrogen peroxide (H2O2) and amyloid β peptide (Aβ), respectively. Compounds 1–3 and 5–9 exhibited significant neuroprotective effects against H2O2-induced SH-SY5Y cell apoptosis, and compound 8 exhibited the strongest activity with a improvement of cell viability by about 30% at the concentration of 10?μM. Compounds 1–9 showed significant neuroprotective effects against Aβ-induced SH-SY5Y cell apoptosis.
Diplomorphanins A and B: New C-methyl flavonoids from Diplomorpha canescens
Devkota, Hari Prasad,Watanabe, Masato,Watanabe, Takashi,Yahara, Shoji
, p. 242 - 244 (2013/03/28)
Two new C-methyl flavonoids, diplomorphanins A (1) and B (2) were isolated from the aerial parts of Diplomorpha canescens ( Meisn.) C. A. Meyer along with a known compound, farrerol 7-O-β-dglucopyranoside (3). Structures of these compounds were determined on the basis of spectroscopic data.
Phenolic compounds from the aerial parts of Diplomorpha canescens
Devkota, Hari Prasad,Watanabe, Masato,Watanabe, Takashi,Yahara, Shoji
experimental part, p. 554 - 556 (2012/05/19)
One new C-methyl flavanone glucoside, farrerol 4′-O-β-D- glucopyranoside (1) was isolated from the aerial parts of Diplomorpha canescens (MEISN.) C. A. MEYER. Fourteen known phenolic compounds such as farrerol (2), luteolin 7-methyl ether 5-O-β-D-glucopyranoside (3), (-)-pinoresinol (4), (-)-lariciresinol (5), (-)-dihydrosesamin (6), (±)-dehydrodiconiferyl alcohol (7), rutarensin (8), umbelliferone (9), coniferyl aldehyde (10), sinapyl aldehyde (11), p-coumaric acid methyl ester (12), p-hydroxybenzaldehyde (13), p-hydroxyacetophenone (14) and syringaldehyde (15) were also isolated for the first time from this plant. Structure of 1 was determined on the basis of spectroscopic data including two dimensional (2D)-NMR, circular dichroism (CD) and by the application of Klyne's rule.
Synthesis and biological activity of flavanone derivatives
Shi, Lei,Feng, Xiu E,Cui, Jing Rong,Fang, Lian Hua,Du, Guan Hua,Li, Qing Shan
scheme or table, p. 5466 - 5468 (2011/01/03)
A series of new flavanone derivatives of farrerol was synthesized by a convenient method. The in vitro anti-tumor activity of these compounds was evaluated against human Bel-7402, HL-60, BGC-823 and KB cell lines, the protein tyrosine kinase (PTK) inhibitor activity was also tested. Their cytoprotective activity was tested using hydrogen peroxide (H2O2)-induced injury in human umbilical vein endothelial cells. Their in vitro anti-atherosclerosis activity was tested on vascular smooth muscle cells by the MTT method using tetrandrine as a positive contrast drug. The structures of all compounds synthesized were confirmed by 1H, 13C NMR and ESI-MS. Most of the compounds exhibited good pharmacological activity and the preliminary structure-activity relationships were described.
