95410-23-4

Basic information

• Product Name: Butanamide, 2-methyl-N-(2-nitrophenyl)-3-oxo-
• CAS NO: 95410-23-4
• Molecular Formula: C11H12N2O4
• Molecular Weight: 236.227
• Mol File: 95410-23-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Butanamide, 2-methyl-N-(2-nitrophenyl)-3-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 2-methyl-N-(2-nitrophenyl)-3-oxo-(95410-23-4)
• EPA Substance Registry System: Butanamide, 2-methyl-N-(2-nitrophenyl)-3-oxo-(95410-23-4)

Safety Data

• Hazardous Substances Data: 95410-23-4(Hazardous Substances Data)

Upstream product

• 87769-39-9 2,2,5,6-tetramethyl-2H,4H-1,3-dioxin-4-one 
• 88-74-4 2-nitro-aniline 

Relevant articles and documents

Synthesis of β-Ketocarboxamide Derivatives Using 2,2-Dimethyl-2H,4H-1,3-dioxin-4-ones

Thermal reaction of 2,2-dimethyl-2H,4H-1,3-dioxin-4-ones (1) with amines was studied.Acylketenes 2, generated by heating of 1, reacted with anilines and benzylamine to give the corresponding β-ketocarboxamides (3,4, and 5) in good yields.The reaction of 1 with ammonia gave 3-amino-2-alkenamides (7), which were hydrolyzed to β-ketocarboxamides (6).The former products 7 were readily transformed to the 6-substituted 2-methyl-3H-pyrimidin-4-ones (9) via the 3-acetamido-2-alkenamides (8).Acylation of O-benzylhydroxylamine with 1 gave the β-ketohydroxamic acids 10.Debenzylation of 10 followed by cyclization gave rise to 5-alkyl-3-hydroxyisoxazoles (12).The reaction of 1 with amides gave the corresponding N-acetylated amides (13). Keywords --- 2H,4H-1,3-dioxin-4-one; thermal fragmentation; acylketene; acylation; carboxamide; hydroxamic acid; 3-hydroxyisoxazole; 3H-pyrimidin-4-one