95416-26-5Relevant academic research and scientific papers
Synthesis of Aniline Derivatives with Potential Toxicological Implications to the Spanish Toxic Oil Syndrome
Ferrer, Marta,Galceran, Montserrat,Sanchez-Baeza, Francisco,Casas, Josefina,Messeguer, Angel
, p. 507 - 512 (2007/10/02)
The synthesis of anilides 2 from several saturated and unsaturated fatty acids 1 required for toxicological studies related to the Spanish Toxic Oil Syndrome is reported.In addition, a simple procedure for the determination of the position of a carbon-carbon double bond of a fatty acid residue is described.This procedure involves epoxidation of the sample with 3,3-dimethyldioxirane followed by oxidative cleavage with periodic acid to yield the corresponding carbonyl derivatives which are easily identifiable by GC-MS analysis.Finally, the synthesis of anilino derivatives 5-8 formally derived from glycerol is also reported.For this purpose, a common precursor, i.e. 3-(phenylamino)propane-1,2-diol (4) is prepared, and convenient procedures for its chemoselective acylation at either the hydroxy or the amino group have been developed. Key Words: Toxic oil syndrome / Aniline / Fatty acids, synthesis of
