954237-04-8Relevant academic research and scientific papers
Novel compounds with potent CDK9 inhibitory activity for the treatment of myeloma
Czudor, Zsófia,Balogh, Mária,Bánhegyi, Péter,Boros, Sándor,Breza, Nóra,Dobos, Judit,Fábián, Márk,Horváth, Zoltán,Illyés, Eszter,Markó, Péter,Sipos, Anna,Szántai-Kis, Csaba,Szokol, Bálint,?rfi, László
, p. 769 - 773 (2018)
Cyclin-dependent kinases (CDKs) and Polo-like kinases (PLKs) play key role in the regulation of the cell cycle. The aim of our study was originally the further development of our recently discovered polo-like kinase 1 (PLK1) inhibitors. A series of new 2,4-disubstituted pyrimidine derivatives were synthesized around the original hit, but their PLK1 inhibitory activity was very poor. However the novel compounds showed nanomolar CDK9 inhibitory activity and very good antiproliferative effect on multiple myeloma cell lines (RPMI-8226).
PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE
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Page/Page column 45, (2010/04/03)
Disclosed are compounds of formula (I) and or salts thereof which activate soluble guanylate cyclase (sGC), pharmaceutical compositions containing them, their use in the manufacture of a medicament for teating cardiovascular diseases, and processes for their preparation.
