954409-40-6

Upstream product

• 2581-34-2 3-methyl-4-nitrophenol 
• 870-63-3 prenyl bromide 

Downstream Products

• 954409-42-8 2,2-dimethyl-3-{[(3-methyl-4-nitrophenyl)oxy]methyl}oxirane 
• 954409-34-8 2-({4-chloro-2-[(3-chloro-5-cyanophenyl)carbonyl]phenyl}oxy)-N-(4-{[2,3-dihydroxy-3-methylbutyl]oxy}-2-methylphenyl)acetamide 
• 954409-44-0 3-methyl-1-[(3-methyl-4-nitrophenyl)oxy]-2,3-butanediol 
• 1056938-02-3 1-[(4-amino-3-methylphenyl)oxy]-3-methyl-2,3-butanediol 

Relevant academic research and scientific papers

The serotonin 5-HT4 receptor. 2. Structure-activity studies of the indole carbazimidamide class of agonists.

A number of substituted indole carbazimidamides were prepared and evaluated as 5-HT4 receptor agonists by using the isolated field-stimulated guinea pig ileum preparation. Their selectivity for the 5-HT4 receptor was established by examining their affinity for other 5-HT receptors using radioligand-binding techniques. Several selective and highly potent full as well as partial agonists emerged from this study. For example, 1b,d were found to be the most potent, full 5-HT4 receptor agonist described so far (EC50 = 0.5 and 0.8 nM, respectively), being 6 and 4 times more potent than serotonin itself. On the other hand, 5b and 1h appeared as partial 5-HT4 receptor agonists in the nonstimulated guinea pig ileum preparation with potencies, evaluated against serotonin action, respectively similar (5b, Ki = 12 nM) to and 300-fold higher (1h, Ki = 0.04 nM) than serotonin.

CHEMCIAL COMPOUNDS

The present invention relates to a compound that is a non-nucleoside reverse transcriptase inhibitor, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compound in the treatment of