954416-17-2

Upstream product

• 91179-57-6 tert-butyl 2-acetyl-3-oxobutanoate 
• 1694-31-1 tert-butyl acetoacetate 
• 954416-13-8 tert-butyl 1-bromomethyl-3-methoxy-9,10-anthraquinone-2-carboxylate 
• 954416-11-6 tert-butyl 3-methoxy-1-methyl-9,10-anthraquinone-2-carboxylate 
• 954416-09-2 3-hydroxy-1-methyl-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester 
• 954416-08-1 tert-butyl 3-(trimethylsilyloxy)-2-(1'-(trimethylsilyloxy)vinyl)but-2-enoate 
• 954416-16-1 1-(2-hydroxymethyl-6-methoxybenzyl)-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester 

Downstream Products

• 960287-24-5 C₃₄H₃₄O₈ 
• 954416-18-3 tert-butyl 1-{2'-[6''-(tert-butyldimethylsilanyloxy)-1''-hydroxyhex-2''-ynyl]-6'-methoxybenzyl}-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate 
• 954416-21-8 tert-butyl 1-[2'-(5''-carboxypentanoyl)-6'-methoxybenzyl]-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate 
• 960287-20-1 1-[2-(1,6-dihydroxyhexyl)-6-methoxybenzyl]-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

METHOD FOR THE PRODUCTION OF MUMBAISTATIN DERIVATIVES

The present invention relates to a process for preparing mumbaistatin derivatives (I), where the anthraquinone skeleton is constructed via a Diels-Alder reaction and the central methylene bridge via a transition metal-catalyzed reaction, and to the interm

Synthesis of a mumbaistatin analogue through cross-coupling

Studies on the total synthesis of mumbaistatin, the strongest natural inhibitor of G6P-T1, have culminated in the synthesis of a 4″,8-dideoxy analogue. Key steps include a Diels-Alder reaction for the construction of the functionalized anthraquinone, a palladium-catalyzed Stille coupling to generate a tetra-ortho-substituted diarylmethane, and a titanium-mediated alkynylation of an aldehyde to complete the carbon skeleton of mumbaistatin. Radical bromination of the methylene bridge afforded a lactone, which resembles the target structure in its cyclized form. Georg Thieme Verlag Stuttgart.