95450-49-0Relevant articles and documents
Le polyphosphate d'ethyle, un reactif de choix pour la synthese de derives du benzofuranne dicarboxylate-2,3 de methyle
Belleney, Joel,Vebrel, Joel,Cerutti, Ernest
, p. 1431 - 1435 (2007/10/02)
The aim of this work is to develop a fast and effective method for the synthesis of methylated derivatives of dimethylbenzofuran-2,3-dicarboxylate.With this end in view, we can suggest significant improvements to the Koelsch and Whitney method, especially by using ethyl polyphosphate.This reagent is indeed well adapted to the cyclodehydration of the methyl 2-aryloxy-3-hydroxymaleate intermediates into benzofuran compounds, since the yield is often better than 80percent.