95450-70-7Relevant academic research and scientific papers
Heterocyclic compounds as well as preparation method and application thereof
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Paragraph 0173; 0174; 0179; 0180, (2018/07/30)
The invention belongs to the field of medicines and particularly relates to heterocyclic compounds with the structural characteristics shown in formula (I) or pharmaceutically acceptable salts, a preparation method and an application of the heterocyclic compounds as a nucleotide oxidative damage repairase MTH1 inhibitor. Pharmacological experiment results indicate that the compounds have significant inhabitation effects on the activity of MTH1 and can be used for preventing and treating clinical diseases related to MTH1.
KETENE-S,N-ACETALS AS SYNTHETIC INTERMEDIATES FOR HETEROCYCLES. A NEW SYNTHESIS OF 4-ARYLAMINOPYRIMIDINES
Takahata, Hiroki,Nakajima, Tomoko,Matoba, Katsuhide,Yamazaki, Takao
, p. 1257 - 1266 (2007/10/02)
Reaction of β-aminothiocarbonyl-α-methylthioenamines (3a-d) derived from ketene-S,N-acetal (1) with benzamidine and guanidine gave 4-arylaminopyrimidines (4a-d and 5a-d), respectively.
