95450-79-6Relevant academic research and scientific papers
Synthesis and herbicidal activities of aryloxyacetic acid derivatives as HPPD inhibitors
Huang, Hao,Liu, Jian-Min,Shu, Lei,Wang, Man-Man,Yan, Yi-Le,Zhang, Da-Yong,Zhang, Jian-Qiu
supporting information, p. 233 - 247 (2020/03/27)
A series of aryloxyacetic acid derivatives were designed and synthesized as 4-hydoxyphenylpyruvate dioxygenase (HPPD) inhibitors. Preliminary bioassay results reveal that these derivatives are promising Arabidopsis thaliana HPPD (AtHPPD) inhibitors, in particular compounds I12 (Ki = 0.011 μM) and I23 (Ki = 0.012 μM), which exhibit similar activities to that of mesotrione, a commercial HPPD herbicide (Ki = 0.013 μM). Furthermore, the newly synthesized compounds show significant greenhouse herbicidal activities against tested weeds at dosages of 150 g ai/ha. In particular, II4 exhibited high herbicidal activity for pre-emergence treatment that was slightly better than that of mesotrione. In addition, compound II4 was safe for weed control in maize fields at a rate of 150 g ai/ha, and was identified as the most potent candidate for a novel HPPD inhibitor herbicide. The compounds described herein may provide useful guidance for the design of new HPPD inhibiting herbicides and their modification.
Le polyphosphate d'ethyle, un reactif de choix pour la synthese de derives du benzofuranne dicarboxylate-2,3 de methyle
Belleney, Joel,Vebrel, Joel,Cerutti, Ernest
, p. 1431 - 1435 (2007/10/02)
The aim of this work is to develop a fast and effective method for the synthesis of methylated derivatives of dimethylbenzofuran-2,3-dicarboxylate.With this end in view, we can suggest significant improvements to the Koelsch and Whitney method, especially by using ethyl polyphosphate.This reagent is indeed well adapted to the cyclodehydration of the methyl 2-aryloxy-3-hydroxymaleate intermediates into benzofuran compounds, since the yield is often better than 80percent.
