954502-27-3

Upstream product

• 444307-98-6 (1S,5R,8S)-2-benzyl-8-(hydroxymethyl)-6,6-dimethyl-3,7-dioxa-2-azabicyclo[3.3.1]nonan-9-one 
• 444307-95-3 (3S,4'S)-2-benzyl-3-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-4-[2-(trimethylsilyl)ethoxy]-3,6-dihydro-2H-1,2-oxazine 

Relevant academic research and scientific papers

Synthesis of Divalent Carbohydrate Mimetics by Reductive Amination with Enantiopure 1,2-Oxazines as Precursors

A direct approach to mono- and divalent carbohydrate mimetics starting from an enantiopure 1,2-oxazine derivative is described. After the Lewis acid induced rearrangement and subsequent reduction to provide the expected bicyclic 1,2-oxazine derivative as

Enantiopure aminopyrans by a lewis acid promoted rearrangement of 1,2-oxazines: Versatile building blocks for oligosaccharide and sugar amino acid mimetics

1,3-Dioxolanyl-substituted 1,2-oxazines, such as syn-l and anti-1, rearrange under Lewis acidic conditions to provide bicyclic products 2-5. Subsequent reductive transformations afforded enantiopure 3-aminopyran derivatives such as 7 and 9 or their protec

Simple modifications of enantiopure 1,2-oxazines leading to building blocks for carbohydrate and peptide mimetics

Starting from easily available enantiopure pyran derivatives we prepared bicyclic γ-lactam 6, azide 10, and alkyne 18 using simple procedures. These compounds were crucial intermediates for the synthesis of γ-amino acid 8 and dipeptide 9 as well as triazo