954571-39-2Relevant academic research and scientific papers
Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors
Chen, Xuxing,Huan, Xiajuan,Liu, Qiufeng,Wang, Yuqin,He, Qian,Tan, Cun,Chen, Yi,Ding, Jian,Xu, Yechun,Miao, Zehong,Yang, Chunhao
supporting information, p. 389 - 403 (2018/01/17)
The nuclear protein poly(ADP-ribose) polymerases-1/2 (PARP-1/2) are involved in DNA repair damaged by endogenous or exogenous process. And PARP-1/2 inhibitors have been proved to be clinically efficacious for DNA repair deficient tumors in the past decade
DIHYDROOROTATE DEHYDROGENASE INHIBITORS
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Page/Page column 70, (2010/11/03)
The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.
