95458-29-0Relevant academic research and scientific papers
A Practical Synthesis of the Anti-tumour Agent 2-Methyl-4-deoxyisopicropodophyllotoxin and Related Podophyllin Analogues
Beard, Andrew R.,Hazell, Sarah J.,Mann, John,Palmer, Christopher
, p. 1235 - 1238 (2007/10/02)
We describe an efficient, six-stage synthesis of 2-methyl-4-deoxyisopicropodophyllotoxin, which proceeds via a Diels-Alder cycloaddition between 2-methylmaleic anhydride and the orthoquinodimethane generated by treatment of 5-1-acetoxy-1-(3',4',5'-trimet
The Synthesis of Lignans and Related Structures using Quinodimethanes and Isobenzofurans: Approaches to the Podophyllins
Mann, John,Piper, Susan E.,Yeung, Lilan K.P.
, p. 2081 - 2088 (2007/10/02)
Novel routes to 1-aryl-5,6-dialkoxy-1,3-dihydrobenzothiophene 2,2-dioxides (13) and to the corresponding benzofuran (8) have been developed; these species yield quinodimethanes (12) via thermal extrusion of SO2 and isobenzofurans (5c) in an acid-cat
