95458-82-5

Upstream product

• 35466-83-2 allyl methyl carbonate 
• 108054-54-2 diethyl (4-chlorophenyl)(hydroxy)methylphosphonate 
• 104-88-1 4-chlorobenzaldehyde 
• 762-04-9 phosphonic acid diethyl ester 
• 814-49-3 diethyl chlorophosphate 
• 873-76-7 para-Chlorobenzyl alcohol 

Downstream Products

• 35424-56-7 1-chloro-4-(iodomethyl)benzene 
• 831-81-2 4-chlorophenyl(phenyl)methane 
• 125055-91-6 4,4′-(2-(4-chlorophenyl)ethene-1,1-diyl)bis(methoxybenzene) 
• 6057-79-0 (S)-(-)-t-butyl(phenyl)phosphine oxide 
• 101-76-8 4,4'-dichlorodiphenylmethane 
• 52094-02-7 o-Chlorophenyl-1-p'-chlorophenylmethane 
• 1007387-36-1 4-(4-chlorobenzyl)thiophene-2-carbaldehyde 
• 6332-83-8 2-(4-chlorophenyl)-1-phenylethanone 
• 6279-35-2 2-(4'-chlorophenyl)-1-phenylethan-1-ol 

Relevant academic research and scientific papers

Palladium/Xiao-Phos-Catalyzed Kinetic Resolution of sec-Phosphine Oxides by P-Benzylation

P-stereogenic tert- and sec-phosphines have wide applications in asymmetric catalysis, materials, and pharmaceutical chemistry, however, their practical synthesis still constitutes a significant challenge. Herein, a successful kinetic resolution of rac-se

Selective Conversion of Benzylic Phosphates into Diarylmethanes Through Al(OTf)3-Catalyzed Friedel–Crafts-Type Benzylation

Al(OTf)3 was identified as a high-performance catalyst for Friedel–Crafts-type benzylation using benzylic phosphates as electrophiles. The reaction proceeded even with 0.2 mol-% of the catalyst. A series of diarylmethanes (21 examples) was obtained in moderate to high yield. The catalyst showed unique chemoselectivity, preferentially converting the benzylic phosphate motif, even with a benzylic acetate group existed in the same molecule.

Palladium-catalysed O-Allylation of α-Hydroxyphosphonates: An Expedient Entry into Phosphono-oxaheterocycles

We report here an unprecedented palladium-catalysed O-allylation of α-hydroxyphosphonates. The method was eventually included in a sequential Pudovik/Tsuji-Trost type O-allylation/Ring-Closing Metathesis to afford a variety of phosphorylated heterocycles

BuLi-triggered phospha-Brook rearrangement: Efficient synthesis of organophosphates from ketones and aldehydes

A variety of organophosphates are synthesized from n-BuLi-triggered, (additional) solvent-free reactions of diethyl phosphite with both activated/unactivated ketones and aldehydes preferably at room temperature via phospha-Brook rearrangement. We could successfully synthesize the naphthylic/allylic phosphates using this approach.

Synthesis of diarylmethanes through palladium-catalyzed coupling of benzylic phosphates with arylsilanes

An efficient approach to the benzylation of arenes has been developed. The reactions described provide straightforward access to diarylmethanes through Pd-catalyzed coupling of benzylic phosphates with arylsilanes in good to excellent yields. The reaction tolerates a wide range of functionalities such as halide, alkoxyl, and nitro groups.

Suzuki-Miyaura cross-coupling of benzylic phosphates with arylboronic acids

(Chemical Equation Presented) Suzuki-Miyaura cross-coupling of benzylic phosphates with arylboronic acids was investigated. Optimum conditions employed the simple catalytic system of palladium(II) acetate (1 mol %) and triphenylphosphine (4 mol %) with either potassium phosphate or potassium carbonate as the base and toluene as the solvent at 90°C. Using the developed conditions, a series of structurally diverse diarylmethanes were prepared.