95463-24-4

Upstream product

• 32469-24-2 (1R,3R,4R,5R)-(-)-quinic acid tetraacetate 
• 23804-28-6 (-)-1,3,4,5-Tetra-O-acetylquinic acid 
• 77-95-2 D-(-)-quinic acid 

Downstream Products

• 99646-33-0 1,3,4,5-Tetrahydroxy-cyclohexanecarboxylic acid (naphthalen-1-ylmethyl)-amide 
• 99646-29-4 1,3,4,5-Tetrahydroxy-cyclohexanecarboxylic acid naphthalen-1-ylamide 
• 24367-44-0 2-(2-tert-butyldisulfanyl)pyridine 
• 92822-52-1 2-((3S,5S)-1,3,4,5-Tetraacetoxy-cyclohexylmethyl)-acrylic acid ethyl ester 
• 66325-66-4 1β,2β,3α,5αβ-tetraacetoxycyclohexane 
• 89031-75-4 (3R,5R)-1,3,4,5-Tetraacetoxy-cyclohexanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester 
• 89025-64-9 1αβ,3β,4β,5α-tetraacetoxy-1αβ(2'-pyridylthio)cyclohexane 
• 97732-71-3 C₂₆H₃₄N₂O₁₀ 
• 860812-24-4 (2S,3R)-3-tert-Butoxy-2-[((3R,5R)-1,3,4,5-tetraacetoxy-cyclohexanecarbonyl)-amino]-butyric acid methyl ester 

Relevant academic research and scientific papers

Novel quercetin derivatives, their preparation, pharmaceutical compositions containing them and their use

The invention relates to novel quercetin derivatives and pharmaceutically acceptable salts, hydrates, and solvates and dimers thereof; a process for the preparation of the novel quercetin derivatives and pharmaceutically acceptable salts, hydrates, and so

Sialyl Lewisx analogs based on a quinic acid scaffold as the fucose mimic

(-)-Quinic acid was used as a starting material for the preparation of sialyl Lewisx mimetics in order to target E-selectin. Spatial orientation of the hydroxyl groups of quinic acid could mimic the L-fucose ones. Introduction of a side chain ending with a carboxylic acid was effected to replace the sialic acid interaction at the carbohydrate recognition domain. A first series of derivatives, incorporating amino acids linked to quinic acid, were tested for their affinity and found to interact with E-selectin with IC50 within the millimolar range.

THE INVENTION OF NEW RADICAL CHAIN REACTIONS. PART VIII. RADICAL CHEMISTRY OF THIOHYDROXAMIC ESTERS; A NEW METHOD FOR THE GENERATION OF CARBON RADICALS FROM CARBOXYLIC ACIDS.

The aliphatic and alicyclic esters of N-hydroxy-pyridine-2-thione are readily reduced by tributylstannane in a radical chain reaction to furnish nor-alkanes.In the absence of the stannane a smooth decarboxylative rearrangement occurs to give 2-substituted thiopyridines.The radicals present in this reaction provoke with t-butylthiol an efficient radical reaction with formation of nor-alkane and 2-pyridyl-t-butyl disulphide.Similarly these carbon radicals can be captured by halogen atom transfer to give noralkyl chlorides, bromides and iodides.With oxygen in the presence of t-butylthiol the corresponding noralkyl hydroperoxides are formed in another radical chain reaction.