955005-16-0Relevant academic research and scientific papers
First total synthesis of sterenins A, C and D
Shinozuka, Tsuyoshi,Yamamoto, Yuko,Hasegawa, Toru,Saito, Keiji,Naito, Satoru
, p. 1619 - 1622 (2008/09/18)
The first total synthesis of sterenins A, C and D, potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), is described. The prenyl group was regioselectively introduced by a Claisen rearrangement, whereas the construction of an isoindolinone skeleton was accomplished by the lactamization of lactones assisted by a phenolic hydroxyl group.
