955028-67-8

Basic information

• Product Name: 6-Azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester
• Synonyms: 6-Azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester;6-Azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester;tert-Butyl 6-azaspiro[2.5]octane-6-carboxylate;6-Azaspiro[2.5]Octane-6-Carboxylic Acid, 1,1-Dimethylethyl Ester(WX100459)
• CAS NO: 955028-67-8
• Molecular Formula: C12H21NO2
• Molecular Weight: 211.30064
• Mol File: 955028-67-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester(955028-67-8)
• EPA Substance Registry System: 6-Azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester(955028-67-8)

Safety Data

• Hazardous Substances Data: 955028-67-8(Hazardous Substances Data)

Upstream product

• 159635-49-1 tert-butyl 4-methylidenepiperidine-1-carboxylate 
• 1037834-61-9 N-cbz-6-azaspiro[2.5]octane 
• 75-11-6 diiodomethane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1260527-32-9 6-azaspiro[2.5]octane hydrobromide 

Downstream Products

• 1260527-41-0 (+/-)-(2-methyl-5-phenylthiazol-4-yl)(5-((6-methylpyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)methanone 
• 1260527-43-2 (+/-)-(2-methyl-5-phenylthiazol-4-yl)(5-((5-(trifluoromethyl)pyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)methanone 
• 1260527-40-9 (+/-)methyl 2-(6-azaspiro[2.5]octan-5-ylmethylamino)-5-chlorobenzoate 
• 1260527-42-1 (+/-)-(5-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone 
• 1260527-45-4 (+/-)-(5-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-(cyclopropylmethoxy)phenyl)methanone 
• 1260527-46-5 (+/-)-(5-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone 
• 1260527-47-6 (+/-)-(5-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone 
• 1260527-48-7 (+/-)-(5-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone 
• 1260527-49-8 (+/-)-methyl 5-chloro-2-((6-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-azaspiro[2.5]octan-5-yl)methylamino)benzoate 
• 872-64-0 6-azaspiro[2.5] octane 
• 1417743-86-2 methyl 4-(1-(6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl)benzoate 2,2,2-trifluoroacetate 

Relevant articles and documents

Bromomethyl Silicate: A Robust Methylene Transfer Reagent for Radical-Polar Crossover Cyclopropanation of Alkenes

A general protocol for visible-light-induced cyclopropanation of alkenes was developed with bromomethyl silicate as a methylene transfer reagent, offering a robust tool for accessing highly valuable cyclopropanes. In addition to α-aryl or methyl-substituted Michael acceptors and styrene derivatives, the unactivated 1,1-dialkyl ethylenes were also shown to be viable substrates. Apart from realizing the cyclopropanation of terminal alkenes, the methyl transfer reaction has been further demonstrated to be amenable to the internal olefins. The photocatalytic cyclopropanation of 1,3-bis(1-arylethenyl)benzenes was also achieved, giving polycyclopropane derivatives in excellent yields. With late-stage cyclopropanation as the key strategy, the synthetic utility of this transformation was also demonstrated by the total synthesis of LG100268.

Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction

The invention concerns a spiro-amino compound of Formula (VI) wherein m is 1 or 2 or 3, n is 1 or 2, R is selected from a 5- or 6-membered aromatic ring and a 5-or 6-membered heteroaromatic ring comprising 1 to 3 heteroatoms selected from S, O e N, such r