955035-83-3Relevant academic research and scientific papers
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs
Stocks, Paul A.,Bray, Patrick G.,Barton, Victoria E.,Al-Helal, Mohammed,Jones, Michael,Araujo, Nuna C.,Gibbons, Peter,Ward, Stephen A.,Hughes, Ruth H.,Biagini, Giancarlo A.,Davies, Jill,Amewu, Richard,Mercer, Amy E.,Ellis, Gemma,O'Neill, Paul M.
, p. 6278 - 6283 (2007)
(Chemical Equation Presented) The iron-y of fate: Isobole analyses of fluorescently labeled antimalarial endoperoxides with chelators selective for non-heme iron, and laser confocal microscopy studies within living malaria parasites have shown that the semisynthetic analogues of artemisinin and synthetic endoperoxides (see example) share a common mechanism of action involving chelatable-iron-mediated bioactivation (see images) and irreversible alkylation of parasite targets.
