10Panx, also known as L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-tyrosine, is a connexin mimetic peptide that specifically inhibits pannexin-1 gap junctions. It is a promising pharmaceutical candidate for various applications due to its ability to modulate cellular communication and signaling pathways.
955091-53-9
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Basic information
- Product Name: 10Panx
- Synonyms: 10Panx
- CAS NO:955091-53-9
- Molecular Formula: C58H79N15O16
- Molecular Weight: 1242.36
- EINECS: N/A
- Product Categories: peptides
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: 1.48±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: ≥124.2 mg/mL in DMSO; insoluble in EtOH; ≥4.26 mg/mL in H2O with ultrasonic
- PKA: 3.05±0.10(Predicted)
- CAS DataBase Reference: 10Panx(CAS DataBase Reference)
- NIST Chemistry Reference: 10Panx(955091-53-9)
- EPA Substance Registry System: 10Panx(955091-53-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 955091-53-9(Hazardous Substances Data)
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955091-53-9 Usage
Uses
Used in Pharmaceutical Industry:10Panx is used as a connexin mimetic peptide for inhibiting pannexin-1 gap junctions, which play a crucial role in cellular communication and signaling pathways. This inhibition can be employed for the development of therapeutic agents targeting various diseases and conditions.
Used in Research Applications:
10Panx is used as a research tool for studying the role of pannexin-1 channels in various cellular processes, including inflammation, cell death, and tissue repair. By inhibiting these channels, researchers can gain insights into the underlying mechanisms and potential therapeutic targets for various diseases.
Used in Drug Development:
10Panx is used as a lead compound for the development of novel drugs targeting pannexin-1 channels. Its ability to inhibit these channels can be leveraged to develop therapeutic agents for treating various diseases, such as neurodegenerative disorders, inflammatory conditions, and cancer.
Used in Drug Delivery Systems:
10Panx can be incorporated into drug delivery systems to improve the efficacy and bioavailability of therapeutic agents targeting pannexin-1 channels. By encapsulating or conjugating 10Panx with other drugs or nanoparticles, it can enhance the delivery and therapeutic outcomes of these agents.
Biological Activity
10panx is a mimetic inhibitory peptide of panx1, which is a mammalian protein ectopically expressed to function as a hemi-channel, that readily and reversibly inhibits the panx1 currents. 10panx has attracted increasing attention as it allows scientists readily and reliably to examine inhibition of panx1 in cells where efficient and consistent delivery of sirna is highly difficult. according to results of multiple previous studies, 10panx selectively inhibits p2x7r-induced dye uptake without altering other aspects of r2x7r activation and atp-evoked membrane currents, constitutive dye-uptake and hemichannel-like currents that are induced by the overexpression of panx1, and atp-mediated il-1β release.pablo pelegrin and annmarie surprenant. pannexin-1 mediates large pore formation and interleukin-1β release by the atp-gated p2x7 receptor. the embo journal (2006) 25, 5071-5082Check Digit Verification of cas no
The CAS Registry Mumber 955091-53-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,5,0,9 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.Calculate Digit Verification of CAS Registry Number 955091-53:
(8*9)+(7*5)+(6*5)+(5*0)+(4*9)+(3*1)+(2*5)+(1*3)=189
189 % 10 = 9
So 955091-53-9 is a valid CAS Registry Number.
955091-53-9Upstream product
955091-53-9Downstream Products
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10Panx
