95526-04-8

Basic information

• Product Name: 2-{(Z)-phenyl[2-(pyridin-2-yl)hydrazinylidene]methyl}pyridine
• Synonyms: 2-{(Z)-phenyl[2-(pyridin-2-yl)hydrazinylidene]methyl}pyridine
• CAS NO: 95526-04-8
• Molecular Weight: 274.325
• Mol File: 95526-04-8.mol

Chemical Properties

• CAS DataBase Reference: 2-{(Z)-phenyl[2-(pyridin-2-yl)hydrazinylidene]methyl}pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{(Z)-phenyl[2-(pyridin-2-yl)hydrazinylidene]methyl}pyridine(95526-04-8)
• EPA Substance Registry System: 2-{(Z)-phenyl[2-(pyridin-2-yl)hydrazinylidene]methyl}pyridine(95526-04-8)

Safety Data

• Hazardous Substances Data: 95526-04-8(Hazardous Substances Data)

Upstream product

• 4930-98-7 pyrid-2-ylhydrazine 
• 91-02-1 phenyl(pyridin-2-yl)methanone 
• 62437-99-4 2-hydrazinylpyridine dihydrochloride 

Relevant articles and documents

Copper(II) hydrazone complexes with different nuclearities and geometries: Synthesis, structural characterization, antioxidant SOD activity and antiproliferative properties

New copper(II) hydrazone complexes with (Z)-2-(phenyl(2-(pyridin-2-yl)hydrazono)methyl)pyridine (L) were synthesized and characterized using various physicochemical methods. The geometries of the complexes can be classified as mononuclear and binuclear. T

Synthesis of (pyridin-2-yl)hydrazone rhenium(i) tricarbonyl complexes that exhibit ph-sensitive fluorescence

There is great potential for novel diagnostic and therapeutic agents that combine multiple imaging modalities. The combination of optical and radionuclide imaging systems is particularly promising for the improved management of cancer. We describe a new heteroorganometallacyclic system containing the (2-pyridyl)hydrazono-Re(CO)3 that exhibits pH-sensitive photophysical properties. This optical reporter group was easily incorporated into a novel synthetic probe for targeting estrogen receptors in cancer. The efficient complexation conditions are expected to be compatible with 99mTc- radiolabeling to obtain dual function imaging probes.

Synthesis and characterization of penta-coordinated copper(II) complexes with hydrazido based ligand and imidazole as auxiliary ligand

The reaction of (Z)-2-(phenyl(2-(pyridin-2-yl)hydrazono)methyl)pyridine (L) and copper(II) salt in methanol yields a series of five pentacoordinated mononuclear complexes. The molecular formulations of these complexes are as [Cu(L)(ImH)2](ClOs

Synthesis of (pyridin-2-yl)hydrazone rhenium(I) tricarbonyl complexes that exhibit ph-sensitive fluorescence

There is great potential for novel diagnostic and therapeutic agents that combine multiple imaging modalities. The combination of optical and radionuclide imaging systems is particularly promising for the improved management of cancer. We describe a new h

Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: Synthesis and antiproliferative activity

A series of N-heteroaryl hydrazones derived from aryl N-heteroaryl or bis-N-heteroaryl methanones was prepared in search for potential novel antitumor agents. The stereochemistry of these compounds was established by means of NMR spectroscopy. Antiproliferative activity was determined in a panel of human tumor cell lines (CCRF-CEM, Burkitt's lymphoma, HeLa, ZR-75- 1, HT-29, and MEXF 276L) in vitro. Generally, the new compounds were found to be more potent (IC50 = 0.011-0.436 μM) than the ribonucleotide reductase inhibitor hydroxyurea (IC50 = 140 μM). Most of the compounds exhibited the highest activity against Burkitt's lymphoma with an IC50 of 0.011-0.035 μM. [14C]Cytidine incorporation into DNA was quantitated for selected hydrazones (Z-A, E-1, Z-3, Z-4, E-5, Z-5, E-13, E-18, Z-19, Z-24, and E-26) as a measure of the inhibition of ribonucleotide reductase in Burkitt's lymphoma cells. The E-configurated compounds were found to inhibit [14C]cytidine incorporation to a greater extent (IC50 = 0.67-5.05 μM) than the Z-isomers (IC50 = 7.20 to > 10 μM). Principal component analysis of the IC50 values obtained for inhibition of cell proliferation revealed that the cell lines tested can be grouped into three main families showing different sensitivities toward the compounds in our series [(i) CCRF-CEM, Burkitt's lymphoma, and Hela; (ii) HT-29; and (iii) MEXF 276 L].

Stereoisomerization in Heterocyclic Hydrazones Derived from 2-Acylpyridines and their Oxidative Cyclization with Mercury(II) Acetate and Lead Tetra-acetate to Fused 1,2,4-Triazoles and 1,2,3-Triazolium Systems

Hydrazones prepared by coupling 2-acylpyridines with arylhydrazines were isolated predominantly as E-isomers when the acyl substituent R was small (H or Me).When R was a phenyl group significant yields of Z-isomers, containing an intramolecular hydrogen b