95526-07-1Relevant articles and documents
Switching on a signaling pathway with an organoruthenium complex
Williams, Douglas S.,Atilla, G. Ekin,Bregman, Howard,Arzoumanian, Arpine,Klein, Peter S.,Meggers, Eric
, p. 1984 - 1987 (2005)
Like an organic molecule! A chemically inert ruthenium complex acts as a metallopharmaceutic inhibitor of the protein kinase GSK-3 by targeting its ATP-binding site. It is shown to switch on the Wnt signal transduction pathway inside living cells and in X
Pyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-diones: Synthesis, cyclometalation, and protein kinase inhibition
Bregman, Howard,Williams, Douglas S.,Meggers, Eric
, p. 1521 - 1527 (2005)
Synthetic routes to pyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-diones are disclosed and examples for their subsequent transformations into cyclometalated protein kinase inhibitors are presented. Georg Thieme Verlag Stuttgart.