955291-62-0

Basic information

• Product Name: C₂₁H₁₅Cl₂N₃O
• Synonyms: C₂₁H₁₅Cl₂N₃O
• CAS NO: 955291-62-0
• Molecular Weight: 396.276
• Mol File: 955291-62-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₅Cl₂N₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₅Cl₂N₃O(955291-62-0)
• EPA Substance Registry System: C₂₁H₁₅Cl₂N₃O(955291-62-0)

Safety Data

• Hazardous Substances Data: 955291-62-0(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 1019-85-8 2-(4-chlorophenyl)benzimidazole 
• 5343-64-6 2-bromo-N-(4-chlorophenyl)acetamide 

Relevant articles and documents

Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH

Cryptosporidium parasites are important waterborne pathogens of both humans and animals. The Cryptosporidium parvum and Cryptosporidium hominis genomes indicate that the only route to guanine nucleotides is via inosine 5′-monophosphate dehydrogenase (IMPDH). Thus the inhibition of the parasite IMPDH presents a potential strategy for treating Cryptosporidium infections. A selective benzimidazole-based inhibitor of C. parvum IMPDH (CpIMPDH) was previously identified in a high throughput screen. Here we report a structure-activity relationship study of benzimidazole-based compounds that resulted in potent and selective inhibitors of CpIMPDH. Several compounds display potent antiparasitic activity in vitro.