95533-25-8Relevant academic research and scientific papers
4-substituted 1,2,4-triazole derivatives
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, (2008/06/13)
A discrete class of 4-substituted 1,2,4-triazole derivatives are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.
The chemical evolution of N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine (L-741,604) and analogues: Potent and selective agonists for 5-HT(1D) receptors
Sternfeld, Francine,Baker, Raymond,Broughton, Howard B.,Guiblin, Alexander R.,Jelley, Richard A.,Matassa, Victor G.,Reeve, Austin J.,Beer, Margaret S.,Stanton, Josephine A.,Hargreaves, Richard J.,Shepheard, Sara L.,Longmore, Jeanette,Razzaque, Zerin,Graham, Michael I.,Sohal, Bindi,Street, Leslie J.
, p. 1825 - 1830 (2007/10/03)
Optimisation of a series of 5-(heterocyclyl)tryptamines led to the identification of the symmetrically substituted, N-4 linked 1,2,4-triazole as the best indole C-5 substituent for 5-HT(1D) receptor affinity and selectivity. The triazole (8) is the most potent and selective, orally bioavailable, 5-HT(1D) receptor agonist identified to date, showing an order of magnitude greater potency than the clinical compound sumatriptan with improved subtype selectivity.
4-Substituted 1,2,4-triazole derivatives
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, (2008/06/13)
4-substituted 1,2,4-triazole derivatives of formula I: wherein R represents a 2-(dimethylamino)ethyl group, or a group of formula (i) or (ii): or a salt or prodrug thereof;, are selective agonists of 5-HT1-like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.
