955376-01-9Relevant academic research and scientific papers
Carbon glycoside glycosylated tetravalent platinum compound as well as synthesis method and application thereof
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, (2021/07/08)
The invention provides a carbon glycoside glycosylated tetravalent platinum compound, a synthesis method and application thereof. R1 and R2 are independently C1-C4 lower alkanes, R3 is glucose, galactose, mannose and ribose, different sugars are used as raw materials, and a series of carbon glycoside glycosylated tetravalent platinum compounds are synthesized through protection and deprotection reaction and metallization reaction of the sugars. The synthesis method is simple, the used raw materials are cheap and easy to obtain, the glycosylated tetravalent platinum compound has the capacity of targeting glucose transporter protein and has potential application value in the field of cancer treatment, introduction of a C-glucosidic bond enables the series of compounds to have the capacity of resisting hydrolysis of beta-glucosidase, and the compound is expected to be applied to the field of oral antitumor drugs.
Hantzsch-type three-component approach to a new family of carbon-linked glycosyl amino acids. Synthesis of C-glycosylmethyl pyridylalanines
Dondoni, Alessandro,Massi, Alessandro,Aldhoun, Mohammad
, p. 7677 - 7687 (2008/02/13)
(Chemical Equation Presented) C-Glycosylmethyl pyridylalanines reported in this paper constitute a novel family of glycosyl amino acids that contain a pyridine ring linking the carbohydrate and amino acid residues. These amino acids may serve to prepare n
