95541-19-8

Usage

Physical appearance

Yellow crystalline powder This describes the color and form of the compound, which is a yellow-colored solid that forms crystalline structures.

Solubility

Sparingly soluble in water The compound does not dissolve easily in water, which may affect its properties and applications in various processes.

Uses

Intermediate in synthesis of pharmaceuticals and agrochemicals The compound serves as a building block for creating other chemicals used in medications and substances applied in agriculture.

Uses

Dyeing intermediate It is also used as a precursor in the production of dyes, which can be applied to textiles and other materials.

Uses

Organic pigments and optical brighteners The compound contributes to the production of pigments and substances that enhance the brightness of materials.

Chemical structure

Presence of an acetylamino group This functional group (-COCH3NH-) is responsible for various properties, such as its potential anti-inflammatory and analgesic effects.

Chemical structure

Presence of a methyl group The -CH3 group contributes to the compound's structure and reactivity, making it a versatile building block for synthesizing other organic compounds.

Chemical structure

Presence of a nitro group The -NO2 group is responsible for the compound's various properties, including its potential anti-inflammatory and analgesic effects.

Pharmaceutical potential

Anti-inflammatory and analgesic properties These properties make the compound a potential candidate for further research and development in the pharmaceutical industry.

Upstream product

• 4389-45-1 3-methylantranilic acid 
• 5437-38-7 3-methyl-2-nitrobenzoic acid 
• 67081-69-0 2-acetylamino-3-methylbenzoic acid 

Downstream Products

• 908597-08-0 methyl 2-iodo-3-methyl-5-nitrobenzoate 
• 90414-59-8 2-Iodo-3-methyl-5-nitrobenzoic acid 
• 70343-14-5 2-amino-3-methyl-5-nitrobenzoic acid 

Relevant academic research and scientific papers

INHIBITORS OF ENCEPHALITIC ALPHAVIRUSES

Compounds of Formula I and Formula II: pharmaceutical compositions containing them, and use of the compounds as active ingredients to treat infection with alphavirus.

Azobenzene-diamides as Photopharmacological Ligands for Insect Ryanodine Receptor

Photoresponsive ligands are powerful tool compounds for studying receptor function with spatiotemporal resolution. However, to the best of our knowledge, such a ligand is not available for the ryanodine receptor (RyR). Herein, we present a photochromic ligand (PCL) for insect RyR by decorating chlorantraniliprole (CHL) with photoswitchable azobenzene (AB). We demonstrated that one potent ligand, named ABCHL13, shows light-induced reversible trans-cis isomerization and 3.5-fold insecticidal activity decrease toward oriental armyworm (Mythimna separata) after UV-light irradiation, that is, trans-ABCH13 has higher activity than the cis-ABCH13. ABCHL13 enables optical control over intracellular Ca2+ release in dorsal unpaired median (DUM) neurons of M. separata and American cockroach (Periplaneta americana) and cardiac function of P. americana. Our results provide a first photopharmacological toolkit that is applicable to light-dependent regulation of RyR and heart beating.

The synthesis and resolution of 2,2′-, 4,4′-, and 6,6′-substituted chiral biphenyl derivatives for application in the preparation of chiral materials

Various routes were examined for the synthesis of chiral biphenyl species that are substituted at the 2,2′, 4,4′ and 6,6′ positions. Because the biaryl bond is tetrasubstituted, many coupling reactions were not suitable. The most reliable coupling reaction proved to be the Ullmann, which gave the desired product in 82% yield. The products were required as the starting point for the preparation of chiral materials using these as the monomer. For this reason, a route was required that produced large quantities of both enantiomers. The two enantiomers were resolved at the penultimate step by the use of chiral HPLC. A complicating feature proved to be the necessity to have a reactive group at the 4,4′ positions, which would permit polymerization though this point. Ultimately, we employed an Ullmann coupling on a dibrominated arene, which occurred selectively at the more hindered bromine by virtue of the directing effect of an ortho ester substituent.